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Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
DC Field | Value | Language |
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dc.contributor.author | 김윤중 | - |
dc.date.accessioned | 2023-06-02T00:47:03Z | - |
dc.date.available | 2023-06-02T00:47:03Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0885-3185 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194425 | - |
dc.description.abstract | Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029). Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | MOVEMENT DISORDERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Dairy Products / adverse effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease / genetics | - |
dc.subject.MESH | Genome-Wide Association Study | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mendelian Randomization Analysis | - |
dc.subject.MESH | Parkinson Disease* / epidemiology | - |
dc.subject.MESH | Parkinson Disease* / genetics | - |
dc.subject.MESH | Polymorphism, Single Nucleotide / genetics | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Cloé Domenighetti | - |
dc.contributor.googleauthor | Pierre-Emmanuel Sugier | - |
dc.contributor.googleauthor | Ashwin Ashok Kumar Sreelatha | - |
dc.contributor.googleauthor | Claudia Schulte | - |
dc.contributor.googleauthor | Sandeep Grover | - |
dc.contributor.googleauthor | Océane Mohamed | - |
dc.contributor.googleauthor | Berta Portugal | - |
dc.contributor.googleauthor | Patrick May | - |
dc.contributor.googleauthor | Dheeraj R Bobbili | - |
dc.contributor.googleauthor | Milena Radivojkov-Blagojevic | - |
dc.contributor.googleauthor | Peter Lichtner | - |
dc.contributor.googleauthor | Andrew B Singleton | - |
dc.contributor.googleauthor | Dena G Hernandez | - |
dc.contributor.googleauthor | Connor Edsall | - |
dc.contributor.googleauthor | George D Mellick | - |
dc.contributor.googleauthor | Alexander Zimprich | - |
dc.contributor.googleauthor | Walter Pirker | - |
dc.contributor.googleauthor | Ekaterina Rogaeva | - |
dc.contributor.googleauthor | Anthony E Lang | - |
dc.contributor.googleauthor | Sulev Koks | - |
dc.contributor.googleauthor | Pille Taba | - |
dc.contributor.googleauthor | Suzanne Lesage | - |
dc.contributor.googleauthor | Alexis Brice | - |
dc.contributor.googleauthor | Jean-Christophe Corvol | - |
dc.contributor.googleauthor | Marie-Christine Chartier-Harlin | - |
dc.contributor.googleauthor | Eugénie Mutez | - |
dc.contributor.googleauthor | Kathrin Brockmann | - |
dc.contributor.googleauthor | Angela B Deutschländer | - |
dc.contributor.googleauthor | Georges M Hadjigeorgiou | - |
dc.contributor.googleauthor | Efthimos Dardiotis | - |
dc.contributor.googleauthor | Leonidas Stefanis | - |
dc.contributor.googleauthor | Athina Maria Simitsi | - |
dc.contributor.googleauthor | Enza Maria Valente | - |
dc.contributor.googleauthor | Simona Petrucci | - |
dc.contributor.googleauthor | Stefano Duga | - |
dc.contributor.googleauthor | Letizia Straniero | - |
dc.contributor.googleauthor | Anna Zecchinelli | - |
dc.contributor.googleauthor | Gianni Pezzoli | - |
dc.contributor.googleauthor | Laura Brighina | - |
dc.contributor.googleauthor | Carlo Ferrarese | - |
dc.contributor.googleauthor | Grazia Annesi | - |
dc.contributor.googleauthor | Andrea Quattrone | - |
dc.contributor.googleauthor | Monica Gagliardi | - |
dc.contributor.googleauthor | Hirotaka Matsuo | - |
dc.contributor.googleauthor | Yusuke Kawamura | - |
dc.contributor.googleauthor | Nobutaka Hattori | - |
dc.contributor.googleauthor | Kenya Nishioka | - |
dc.contributor.googleauthor | Sun Ju Chung | - |
dc.contributor.googleauthor | Yun Joong Kim | - |
dc.contributor.googleauthor | Pierre Kolber | - |
dc.contributor.googleauthor | Bart P C van de Warrenburg | - |
dc.contributor.googleauthor | Bastiaan R Bloem | - |
dc.contributor.googleauthor | Jan Aasly | - |
dc.contributor.googleauthor | Mathias Toft | - |
dc.contributor.googleauthor | Lasse Pihlstrøm | - |
dc.contributor.googleauthor | Leonor Correia Guedes | - |
dc.contributor.googleauthor | Joaquim J Ferreira | - |
dc.contributor.googleauthor | Soraya Bardien | - |
dc.contributor.googleauthor | Jonathan Carr | - |
dc.contributor.googleauthor | Eduardo Tolosa | - |
dc.contributor.googleauthor | Mario Ezquerra | - |
dc.contributor.googleauthor | Pau Pastor | - |
dc.contributor.googleauthor | Monica Diez-Fairen | - |
dc.contributor.googleauthor | Karin Wirdefeldt | - |
dc.contributor.googleauthor | Nancy L Pedersen | - |
dc.contributor.googleauthor | Caroline Ran | - |
dc.contributor.googleauthor | Andrea C Belin | - |
dc.contributor.googleauthor | Andreas Puschmann | - |
dc.contributor.googleauthor | Clara Hellberg | - |
dc.contributor.googleauthor | Carl E Clarke | - |
dc.contributor.googleauthor | Karen E Morrison | - |
dc.contributor.googleauthor | Manuela Tan | - |
dc.contributor.googleauthor | Dimitri Krainc | - |
dc.contributor.googleauthor | Lena F Burbulla | - |
dc.contributor.googleauthor | Matt J Farrer | - |
dc.contributor.googleauthor | Rejko Krüger | - |
dc.contributor.googleauthor | Thomas Gasser | - |
dc.contributor.googleauthor | Manu Sharma | - |
dc.contributor.googleauthor | Alexis Elbaz | - |
dc.identifier.doi | 10.1002/mds.28902 | - |
dc.contributor.localId | A00796 | - |
dc.relation.journalcode | J02275 | - |
dc.identifier.eissn | 1531-8257 | - |
dc.identifier.pmid | 34997937 | - |
dc.identifier.url | https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.28902 | - |
dc.subject.keyword | dairy intake | - |
dc.subject.keyword | Parkinson's disease | - |
dc.subject.keyword | Mendelian randomization | - |
dc.contributor.alternativeName | Kim, Yun Joong | - |
dc.contributor.affiliatedAuthor | 김윤중 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 857 | - |
dc.citation.endPage | 864 | - |
dc.identifier.bibliographicCitation | MOVEMENT DISORDERS, Vol.37(4) : 857-864, 2022-04 | - |
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