Cited 2 times in
Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet's disease
DC Field | Value | Language |
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dc.contributor.author | 김승원 | - |
dc.contributor.author | 박지혜 | - |
dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2023-05-31T05:52:20Z | - |
dc.date.available | 2023-05-31T05:52:20Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 1478-6354 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194289 | - |
dc.description.abstract | BACKGROUND: Clonal haematopoiesis of indeterminate potential (CHIP) is a predisposition to haematological malignancy whose relationship with chronic inflammatory diseases, such as cardiovascular diseases, has been highlighted. Here, we aimed to investigate the CHIP emergence rate and its association with inflammatory markers in Behçet's disease (BD). METHODS: We performed targeted next-generation sequencing to detect the presence of CHIP using peripheral blood cells from 117 BD patients and 5004 healthy controls between March 2009 and September 2021 and analysed the association between CHIP and inflammatory markers. RESULTS: CHIP was detected in 13.9% of patients in the control group and 11.1% of patients in the BD group, indicating no significant intergroup difference. Among the BD patients of our cohort, five variants (DNMT3A, TET2, ASXL1, STAG2, and IDH2) were detected. DNMT3A mutations were the most common, followed by TET2 mutations. CHIP carriers with BD had a higher serum platelet count, erythrocyte sedimentation rate, and C-reactive protein level; older age; and lower serum albumin level at diagnosis than non-CHIP carriers with BD. However, the significant association between inflammatory markers and CHIP disappeared after the adjustment for various variables, including age. Moreover, CHIP was not an independent risk factor for poor clinical outcomes in patients with BD. CONCLUSIONS: Although BD patients did not have higher CHIP emergence rates than the general population, older age and degree of inflammation in BD were associated with CHIP emergence. © 2023. The Author(s). | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | ARTHRITIS RESEARCH & THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Behcet Syndrome* / diagnosis | - |
dc.subject.MESH | Behcet Syndrome* / genetics | - |
dc.subject.MESH | Blood Sedimentation | - |
dc.subject.MESH | Clonal Hematopoiesis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation / genetics | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Others | - |
dc.contributor.googleauthor | Jihye Park | - |
dc.contributor.googleauthor | Hongyul An | - |
dc.contributor.googleauthor | Jiwoo Lim | - |
dc.contributor.googleauthor | I Seul Park | - |
dc.contributor.googleauthor | Mi Hyun Kim | - |
dc.contributor.googleauthor | Ji Hyung Kim | - |
dc.contributor.googleauthor | Seung Won Kim | - |
dc.contributor.googleauthor | Young Il Koh | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.identifier.doi | 10.1186/s13075-023-03014-w | - |
dc.contributor.localId | A00656 | - |
dc.contributor.localId | A00999 | - |
dc.contributor.localId | A04575 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J00241 | - |
dc.identifier.eissn | 1478-6362 | - |
dc.identifier.pmid | 36864496 | - |
dc.subject.keyword | Behçet’s disease | - |
dc.subject.keyword | Clonal haematopoiesis of indeterminate potential | - |
dc.subject.keyword | Inflammation | - |
dc.contributor.alternativeName | Kim, Seung Won | - |
dc.contributor.affiliatedAuthor | 김승원 | - |
dc.contributor.affiliatedAuthor | 박지혜 | - |
dc.contributor.affiliatedAuthor | 천재희 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.identifier.bibliographicCitation | ARTHRITIS RESEARCH & THERAPY, Vol.25(1) : 33, 2023-03 | - |
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