Association of T Cell Senescence with Radiation Pneumonitis in Patients with Non-small Cell Lung Cancer
Authors
Kyung Hwan Kim ; Hongryull Pyo ; Hoyoung Lee ; Dongryul Oh ; Jae Myoung Noh ; Yong Chan Ahn ; Chang Gon Kim ; Hong In Yoon ; Jiyun Lee ; Sehhoon Park ; Hyun-Ae Jung ; Jong-Mu Sun ; Se-Hoon Lee ; Jin Seok Ahn ; Keunchil Park ; Bo Mi Ku ; Eui-Cheol Shin ; Myung-Ju Ahn
Citation
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.115(2) : 464-475, 2023-02
T cell senescence ; chemoradiotherapy ; non-small cell lung cancer ; peripheral blood ; radiation pneumonitis
Abstract
Purpose: Associations between immunosenescence and radiation pneumonitis (RP) are largely unknown. We aimed to identify a peripheral blood T cell senescence biomarker to predict RP in patients with non-small cell lung cancer (NSCLC). Methods and Materials: Patients with locally advanced NSCLC who received definitive concurrent chemoradiotherapy (dCRT) were prospectively registered (cohort 1, n=23; cohort 2, n=31). Peripheral blood was collected at baseline, during dCRT, and at 1 month post-dCRT. Patients were dichotomized to grade ≥2 (G2+) RP and grade 0-1 (G0-1) RP. Flow cytometry was performed to assess phenotypes and functional properties of T cell subsets. RP incidence was estimated via competing risk analysis. Results: Five and six patients exhibited G2+ RP following dCRT in cohorts 1 and 2, respectively. Patients with G2+ RP exhibited a more aged T cell pool and higher frequencies of senescent CD57