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Non-Alcoholic Fatty Liver Disease with Sarcopenia and Carotid Plaque Progression Risk in Patients with Type 2 Diabetes Mellitus

Authors
 Yongin Cho  ;  Hye-Sun Park  ;  Byung Wook Huh  ;  Yong-Ho Lee  ;  Seong Ha Seo  ;  Da Hea Seo  ;  Seong Hee Ahn  ;  Seongbin Hong  ;  So Hun Kim 
Citation
 DIABETES & METABOLISM JOURNAL, Vol.47(2) : 232-241, 2023-03 
Journal Title
DIABETES & METABOLISM JOURNAL
ISSN
 2233-6079 
Issue Date
2023-03
MeSH
Carotid Artery Diseases* / complications ; Carotid Artery Diseases* / diagnostic imaging ; Carotid Artery Diseases* / epidemiology ; Diabetes Mellitus, Type 2* / complications ; Diabetes Mellitus, Type 2* / epidemiology ; Female ; Humans ; Male ; Non-alcoholic Fatty Liver Disease* / complications ; Non-alcoholic Fatty Liver Disease* / diagnostic imaging ; Non-alcoholic Fatty Liver Disease* / epidemiology ; Plaque, Atherosclerotic* / complications ; Plaque, Atherosclerotic* / diagnostic imaging ; Plaque, Atherosclerotic* / epidemiology ; Sarcopenia* / complications ; Sarcopenia* / diagnostic imaging ; Sarcopenia* / epidemiology
Keywords
Atherosclerosis ; Diabetes mellitus , type 2 ; Fatty liver ; Sarcopenia
Abstract
Background: We aimed to evaluate whether non-alcoholic fatty liver disease (NAFLD) with or without sarcopenia is associated with progression of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM).Methods: We investigated 852 T2DM patients who underwent abdominal ultrasonography, bioelectrical impedance analysis, and carotid artery ultrasonography at baseline and repeated carotid ultrasonography after 6 to 8 years. NAFLD was confirmed by abdominal ultrasonography, and sarcopenia was defined as a sex-specific skeletal muscle mass index (SMI) value <2 standard deviations below the mean for healthy young adults. SMI was calculated by dividing the sum of appendicular skeletal mass by body weight. We investigated the association between NAFLD with or without sarcopenia and the progression of carotid atherosclerosis.Results: Of the 852 patients, 333 (39.1%) were classified as NAFLD without sarcopenia, 66 (7.7%) were classified as sarcopenia without NAFLD, and 123 (14.4%) had NAFLD with sarcopenia at baseline. After 6 to 8 years, patients with both NAFLD and sarcopenia had a higher risk of atherosclerosis progression (adjusted odds ratio, 2.20; P<0.009) than controls without NAFLD and sarcopenia. When a subgroup analysis was performed on only patients with NAFLD, female sex, absence of central obesity, and non-obesity were significant factors related to increased risk of plaque progression risk in sarcopenic patients.Conclusion: NAFLD with sarcopenia was significantly associated with the progression of carotid atherosclerosis in T2DM patients.
Files in This Item:
T202302718.pdf Download
DOI
10.4093/dmj.2021.0355
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hye Sun(박혜선)
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/194230
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