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Risk of recurrence of nail unit melanoma after functional surgery versus amputation
DC Field | Value | Language |
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dc.contributor.author | 노미령 | - |
dc.contributor.author | 오병호 | - |
dc.contributor.author | 정기양 | - |
dc.date.accessioned | 2023-05-31T05:36:39Z | - |
dc.date.available | 2023-05-31T05:36:39Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 0190-9622 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194223 | - |
dc.description.abstract | Background: Minimally invasive nail unit melanoma (NUM) can be treated with functional surgery (FS) instead of amputation. Objective: To determine risk factors associated with recurrence in NUM. Methods: We retrospectively reviewed patients with NUM between 2008 and 2022 at a tertiary referral center. Multivariable Cox regression models adjusted for male sex and Breslow thickness (BT) were generated. Receiver operating characteristic analysis was performed to determine optimal cut-off points of the BT for stratifying recurrence risk. Results: We evaluated 140 NUM cases (33 amputation and 107 FS). The mean BT values were 3.14 ± 2.62 mm (amputation) and 0.70 ± 1.36 mm (FS). Recurrence occurred in 10 (30.30%) patients with amputation and 23 (21.5%) with FS. Distant disease occurred in 10 (30.30%) patients with amputation and 8 (7.48%) with FS. Male sex, greater BT, amelanotic color, ulcers, and nodules were associated with greater risk for recurrence or distant disease. A BT of 0.8 mm was deemed the optimal cut-off for stratifying recurrence risk after surgery (odds ratio, 5.32; 95% CI, 2.04-13.85). Limitations: Small sample. Conclusion: FS can be considered for NUM with a BT < 0.8 mm, providing an amputation-sparing benefit. However, NUM with risk factors for recurrence requires patient counselling and close follow-ups. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mosby | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Amputation, Surgical | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Melanoma* / epidemiology | - |
dc.subject.MESH | Melanoma* / surgery | - |
dc.subject.MESH | Nail Diseases* / epidemiology | - |
dc.subject.MESH | Nail Diseases* / surgery | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Skin Neoplasms* / surgery | - |
dc.title | Risk of recurrence of nail unit melanoma after functional surgery versus amputation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Byung Ho Oh | - |
dc.contributor.googleauthor | Solam Lee | - |
dc.contributor.googleauthor | Jung Won Park | - |
dc.contributor.googleauthor | Ju Yeong Lee | - |
dc.contributor.googleauthor | Mi Ryung Roh | - |
dc.contributor.googleauthor | Kyoung Ae Nam | - |
dc.contributor.googleauthor | Kee Yang Chung | - |
dc.identifier.doi | 10.1016/j.jaad.2022.12.039 | - |
dc.contributor.localId | A01278 | - |
dc.contributor.localId | A02367 | - |
dc.contributor.localId | A03582 | - |
dc.relation.journalcode | J01766 | - |
dc.identifier.eissn | 1097-6787 | - |
dc.identifier.pmid | 36642330 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0190962223000634 | - |
dc.subject.keyword | Breslow thickness | - |
dc.subject.keyword | distant disease | - |
dc.subject.keyword | functional surgery | - |
dc.subject.keyword | nail unit melanoma | - |
dc.subject.keyword | recurrence | - |
dc.subject.keyword | survival | - |
dc.contributor.alternativeName | Roh, Mi Ryung | - |
dc.contributor.affiliatedAuthor | 노미령 | - |
dc.contributor.affiliatedAuthor | 오병호 | - |
dc.contributor.affiliatedAuthor | 정기양 | - |
dc.citation.volume | 88 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1017 | - |
dc.citation.endPage | 1023 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol.88(5) : 1017-1023, 2023-05 | - |
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