Cited 2 times in
Plasma Antiretinal Autoantibody Profiling and Diagnostic Efficacy in Patients With Autoimmune Retinopathy
DC Field | Value | Language |
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dc.contributor.author | 이승규 | - |
dc.date.accessioned | 2023-03-27T02:42:50Z | - |
dc.date.available | 2023-03-27T02:42:50Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 0002-9394 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193675 | - |
dc.description.abstract | Purpose: To evaluate plasma antiretinal autoantibody (ARA) profiling and diagnostic efficacy for autoimmune retinopathy (AIR). Design: A multicenter, diagnostic evaluation study. Methods: Forty-nine patients with a clinical diagnosis of AIR, disease controls including 20 patients with retinitis pigmentosa (RP), and 30 normal controls were included. Plasma samples from patients were analyzed for the presence of 6 ARAs, including recoverin, α-enolase, carbonic anhydrase II, heat shock protein 60, aldolase C, and cone-rod homeobox/cone-rod retinal dystrophy 2 using western blotting. Results: Autoantibody detection rates against cone-rod homeobox/cone-rod retinal dystrophy 2, heat shock protein 60, and aldolase C in AIR were 67.3%, 40.8%, and 42.9%, respectively, which were higher than those in RP and normal controls (P < .001, P < .001, and P = .007, respectively), but recoverin, α-enolase, and carbonic anhydrase II were not different from other control groups (P = .117, P = .774, and P = .467, respectively). Among ARAs, antirecoverin antibody was the most specific, as it was found in 3 (6.1%) patients with AIR and none of the control groups. As the number of detected ARAs increased, the probability of AIR increased (odds ratio: 1.913; P < .001; 95% confidence interval: 1.456-2.785). The positive number of ARAs was significantly higher when photoreceptor disruption was observed on optical coherence tomography, or severe dysfunction was observed in electroretinography (P = .022 and P = .029, respectively). Conclusions: The profiles of ARAs in the AIR group were different from those in the RP and normal controls. The higher number of positive ARAs suggests a higher possibility of AIR diagnosis. ARAs should be used as adjunct tools for the clinical diagnosis of AIR. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Autoantibodies | - |
dc.subject.MESH | Autoimmune Diseases* / diagnosis | - |
dc.subject.MESH | Carbonic Anhydrase II | - |
dc.subject.MESH | Chaperonin 60 | - |
dc.subject.MESH | Cone-Rod Dystrophies* | - |
dc.subject.MESH | Electroretinography | - |
dc.subject.MESH | Fructose-Bisphosphate Aldolase | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Phosphopyruvate Hydratase | - |
dc.subject.MESH | Recoverin | - |
dc.subject.MESH | Retinal Diseases* / diagnosis | - |
dc.subject.MESH | Retinitis Pigmentosa* / diagnosis | - |
dc.title | Plasma Antiretinal Autoantibody Profiling and Diagnostic Efficacy in Patients With Autoimmune Retinopathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Seok Hyun Bae | - |
dc.contributor.googleauthor | Hye Kyoung Hong | - |
dc.contributor.googleauthor | Jong Young Lee | - |
dc.contributor.googleauthor | Min Seok Kim | - |
dc.contributor.googleauthor | Christopher Seungkyu Lee | - |
dc.contributor.googleauthor | Min Sagong | - |
dc.contributor.googleauthor | Sook Young Kim | - |
dc.contributor.googleauthor | Baek-Lok Oh | - |
dc.contributor.googleauthor | Young Hee Yoon | - |
dc.contributor.googleauthor | Jae Pil Shin | - |
dc.contributor.googleauthor | Young Joon Jo | - |
dc.contributor.googleauthor | Kwangsic Joo | - |
dc.contributor.googleauthor | Sang Jun Park | - |
dc.contributor.googleauthor | Kyu Hyung Park | - |
dc.contributor.googleauthor | Se Joon Woo | - |
dc.identifier.doi | 10.1016/j.ajo.2022.07.005 | - |
dc.contributor.localId | A02913 | - |
dc.relation.journalcode | J00097 | - |
dc.identifier.eissn | 1879-1891 | - |
dc.identifier.pmid | 35853491 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0002939422002719 | - |
dc.contributor.alternativeName | Lee, Christopher Seungkyu | - |
dc.contributor.affiliatedAuthor | 이승규 | - |
dc.citation.volume | 245 | - |
dc.citation.startPage | 145 | - |
dc.citation.endPage | 154 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.245 : 145-154, 2023-01 | - |
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