Cited 11 times in
Induction and maintenance of remission with mycophenolate mofetil in ANCA-associated vasculitis: a systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2023-03-21T07:16:46Z | - |
dc.date.available | 2023-03-21T07:16:46Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193288 | - |
dc.description.abstract | Background: Uncertainties exist about the use of mycophenolate mofetil (MMF) in anti-neutrophil cytoplasmatic antibody (ANCA)-associated vasculitis (AAV), particularly for remission maintenance. Methods: Systematic review and meta-analysis of phase II and III trials assessing the use of MMF in AAV, granulomatosis with polyangiitis and microscopic polyangiitis (MPA). A comprehensive search of several databases (Medline, EMBASE, Cochrane, Web of Science, Scopus) from inception to 5 May 2020 has been conducted. Trial data were extracted to estimate odds ratios (ORs) and estimates (ES) for MMF efficacy (remission-induction and maintenance). Severe adverse effects (SAEs) were collected. Results: From 565 articles captured, 10 met the predefined criteria, 5 phase II and 5 III trials; 4 assessed remission-induction, 3 remission maintenance and 3 both. The pooled OR for remission-induction at 6 months was 1.06 (95% confidence interval 0.74, 1.52), with no significant difference by subgroup meta-analysis of trials stratified by different study-level features (i.e. kidney disease, MPA, myeloperoxidase-ANCA positivity, newly diagnosed disease) (P > 0.05). The overall ES for remission maintenance at the end of follow-up ranged between 51% and 91% (I2 = 74.8%). Subgroup meta-analysis identified kidney involvement as a possible source of heterogeneity, yielding a significantly higher rate of sustained remission in trials enrolling only patients with kidney involvement (92%, 76-100%) versus those enrolling patients with and without kidney involvement (56%, 45-66%). Results were similar in multiple sensitivity analyses. During follow-up, the frequency of SAEs in MMF-based treatment arms was 31.8%. Conclusions: In AAV, MMF use was significantly associated with higher sustained remission rates in trials enrolling only patients with kidney involvement. These findings might influence clinical practice. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / drug therapy OR Antibodies, Antineutrophil Cytoplasmic OR Humans OR Immunosuppressive Agents / therapeutic use OR Microscopic Polyangiitis* OR Mycophenolic Acid / therapeutic use OR Peroxidase OR Remission Induction | - |
dc.title | Induction and maintenance of remission with mycophenolate mofetil in ANCA-associated vasculitis: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Alvise Berti | - |
dc.contributor.googleauthor | Mouaz Alsawas | - |
dc.contributor.googleauthor | Tabinda Jawaid | - |
dc.contributor.googleauthor | Larry J Prokop | - |
dc.contributor.googleauthor | Jiwon M Lee | - |
dc.contributor.googleauthor | Gwang Hun Jeong | - |
dc.contributor.googleauthor | Luis F Quintana | - |
dc.contributor.googleauthor | Sergey Moiseev | - |
dc.contributor.googleauthor | Augusto Vaglio | - |
dc.contributor.googleauthor | Vladimir Tesar | - |
dc.contributor.googleauthor | Duvuru Geetha | - |
dc.contributor.googleauthor | Jae I L Shin | - |
dc.contributor.googleauthor | Andreas Kronbichler | - |
dc.identifier.doi | 10.1093/ndt/gfab357 | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J02316 | - |
dc.identifier.eissn | 1460-2385 | - |
dc.identifier.pmid | 34910216 | - |
dc.identifier.url | https://academic.oup.com/ndt/article/37/11/2190/6462928 | - |
dc.subject.keyword | ANCA-associated vasculitis | - |
dc.subject.keyword | MMF | - |
dc.subject.keyword | granulomatosis with polyangiitis | - |
dc.subject.keyword | microscopic polyangiitis | - |
dc.subject.keyword | mycophenolate mofetil | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2190 | - |
dc.citation.endPage | 2200 | - |
dc.identifier.bibliographicCitation | NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.37(11) : 2190-2200, 2022-10 | - |
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