Cited 1 times in
Characteristics and outcomes of heart transplant recipients with a pretransplant history of malignancy
DC Field | Value | Language |
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dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2023-03-03T03:13:54Z | - |
dc.date.available | 2023-03-03T03:13:54Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 1600-6135 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/193006 | - |
dc.description.abstract | We aimed to investigate the characteristics and outcomes of HTx recipients with a history of pretransplant malignancy (PTM). Among 1062 HTx recipients between 1997 and 2013, 73 (7.1%) patients had PTMs (77 cancer cases). We analyzed post-HTx outcome, recurrence of PTM, and development of de novo malignancies. Post-HTx outcome included overall survival, 10-year survival, 10-year freedom from cardiac allograft vasculopathy (CAV), non-fatal major adverse cardiac events (NF-MACE), any treated rejection (ATR), acute cellular rejection (ACR), and antibody-mediated rejection (AMR). Four most common PTMs were lymphoproliferative disorders (18.2%), prostate cancers (18.2%), non-melanoma skin cancers (18.2%), and breast cancers (13.0%). Median time from PTM and HTx was 9.0 years. During a median follow-up of 8.6 years after HTx, patients with PTM, compared to those without, showed significantly higher incidence of posttransplant malignancies (43.8% vs. 20.8%, p < .001) including 9.6% (n = 7) of PTM recurrences. However, patients with PTM, compared to those without, showed comparable overall survival, 10-year survival, 10-year freedom from CAV, NF-MACE, ATR, ACR, and AMR. Therefore, a history of PTM should not disqualify patients from HTx listing, while further research is necessary for early detection of posttransplant malignancies in these patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antibodies | - |
dc.subject.MESH | Graft Rejection / diagnosis | - |
dc.subject.MESH | Heart Transplantation* / adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Lymphoproliferative Disorders* / etiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasm Recurrence, Local / etiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Characteristics and outcomes of heart transplant recipients with a pretransplant history of malignancy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Jong-Chan Youn | - |
dc.contributor.googleauthor | Darae Kim | - |
dc.contributor.googleauthor | Kyung An Kim | - |
dc.contributor.googleauthor | Jin-Jin Kim | - |
dc.contributor.googleauthor | In-Cheol Kim | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Jin-Oh Choi | - |
dc.contributor.googleauthor | Eun-Seok Jeon | - |
dc.contributor.googleauthor | Keith Nishihara | - |
dc.contributor.googleauthor | Evan P Kransdorf | - |
dc.contributor.googleauthor | David H Chang | - |
dc.contributor.googleauthor | Michelle M Kittleson | - |
dc.contributor.googleauthor | Jignesh K Patel | - |
dc.contributor.googleauthor | Danny Ramzy | - |
dc.contributor.googleauthor | Fardad Esmailian | - |
dc.contributor.googleauthor | Jon A Kobashigawa | - |
dc.identifier.doi | 10.1111/ajt.17186 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J00121 | - |
dc.identifier.eissn | 1600-6143 | - |
dc.identifier.pmid | 36050598 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S160061352300045X | - |
dc.subject.keyword | heart transplant | - |
dc.subject.keyword | posttransplant malignancy | - |
dc.subject.keyword | pretransplant malignancy | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | recurrence | - |
dc.subject.keyword | survival | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2942 | - |
dc.citation.endPage | 2950 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF TRANSPLANTATION, Vol.22(12) : 2942-2950, 2022-12 | - |
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