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Prostate-Specific Antigen Bounce after 125I Brachytherapy Using Stranded Seeds with Intraoperative Optimization for Prostate Cancer
DC Field | Value | Language |
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dc.contributor.author | 조재호 | - |
dc.contributor.author | 김태형 | - |
dc.contributor.author | 이준복 | - |
dc.date.accessioned | 2022-12-22T04:38:15Z | - |
dc.date.available | 2022-12-22T04:38:15Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192181 | - |
dc.description.abstract | Prostate-specific antigen (PSA) bounce is common in patients undergoing 125I brachytherapy (BT), and our study investigated its clinical features. A total of 100 patients who underwent BT were analyzed. PSA bounce and large bounce were defined as an increase of ≥0.2 and ≥2.0 ng/mL above the initial PSA nadir, respectively, with a subsequent decline without treatment. Biochemical failure was defined using the Phoenix definition (nadir +2 ng/mL), except for a large bounce. With a median follow-up of 49 months, 45% and 7% of the patients experienced bounce and large bounce, respectively. The median time to bounce was 24 months, and the median PSA value at the bounce spike was 1.62 ng/mL, a median raise of 0.44 ng/mL compared to the pre-bounce nadir. The median time to bounce recovery was 4 months. The post-bounce nadir was obtained at a median of 36 months after low-dose-rate BT. On univariate analysis, age, the PSA nadir value at 2 years, and prostate volume were significant factors for PSA bounce. The PSA nadir value at 2 years remained significant in multivariate analysis. We should carefully monitor young patients with high prostate volume having a >0.5 PSA nadir value at 2 years for PSA bounce. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Prostate-Specific Antigen Bounce after 125I Brachytherapy Using Stranded Seeds with Intraoperative Optimization for Prostate Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Tae Hyung Kim | - |
dc.contributor.googleauthor | Jason Joon Bock Lee | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.identifier.doi | 10.3390/cancers14194907 | - |
dc.contributor.localId | A03901 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 36230829 | - |
dc.subject.keyword | bounce | - |
dc.subject.keyword | brachytherapy | - |
dc.subject.keyword | prognostic factor | - |
dc.subject.keyword | prostate cancer | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | 조재호 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 4907 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.14(19) : 4907, 2022-10 | - |
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