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Usefulness and potential pitfalls of pre-operative PET-CT in patients with endometrial cancer undergoing one- and two-step sentinel lymph node mapping: Do negative findings on PET-CT negativity really indicate node negativity?
DC Field | Value | Language |
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dc.contributor.author | 강원준 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 남은지 | - |
dc.contributor.author | 이정윤 | - |
dc.contributor.author | 김상운 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 이용재 | - |
dc.contributor.author | 김유나 | - |
dc.contributor.author | 차종태 | - |
dc.date.accessioned | 2022-12-22T04:03:18Z | - |
dc.date.available | 2022-12-22T04:03:18Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/192025 | - |
dc.description.abstract | Objective: We investigated the utility of Positron emission tomography-Computed tomography (PET-CT) in the setting of two different sentinel lymph node (SLN) mapping techniques; the conventional cervical injection method (one-step) and the two-step method, which involves fundal injection followed by cervical injection. Methods: Patients with endometrial cancer undergoing FDG PET-CT followed by laparoscopic or robotic surgical staging with SLN mapping at the Yonsei Cancer Center between July 2014 and April 2021 were stratified into the PET-positive group (with suspected or likely lymph nodes metastasis) and PET-negative group. A chart review was performed for the number of harvested SLNs, patterns of SLN metastases, and recurrence. Results: Among 466 patients undergoing one-step (n = 276) and two-step (n = 190) SLN mapping, LN metastasis was identified in 21 of 434 PET-negative and 18 of 32 PET-positive patients. The sensitivity and specificity of PET-CT for diagnosing lymph node metastasis were 46.2% and 96.7%, respectively. Among PET-positive patients with LN metastasis, anatomical distribution was concordant in 14/18 patients (77.8%). Among PET-negative patients, four (2.3%) had metastatic para-aortic SLNs, including three (1.7%) with isolated para-aortic metastases; metastatic para-aortic SLNs were exclusively found in the two-step group. Among PET-positive patients, para-aortic SLN metastasis was identified in 35.7% of two-step and 16.7% of one-step group. Among the 21 PET false-negative patients, recurrence was seen in four patients (19%) after a median follow-up of 34 months (range: 7-70 months). Conclusions: PET-CT served as a useful guide to clinicians with high anatomical concordance rate in patients with LN metastasis. However, despite high specificity, sensitivity was limited. SLN metastasis pattern, especially at the para-aortic level, indicates that the two-step SLN technique might be useful in PET-negative and PET-positive patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.relation.isPartOf | GYNECOLOGIC ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Endometrial Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Endometrial Neoplasms* / pathology | - |
dc.subject.MESH | Endometrial Neoplasms* / surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Node Excision | - |
dc.subject.MESH | Lymph Nodes / diagnostic imaging | - |
dc.subject.MESH | Lymph Nodes / pathology | - |
dc.subject.MESH | Lymph Nodes / surgery | - |
dc.subject.MESH | Lymphatic Metastasis / diagnostic imaging | - |
dc.subject.MESH | Lymphatic Metastasis / pathology | - |
dc.subject.MESH | Positron Emission Tomography Computed Tomography / methods | - |
dc.subject.MESH | Sentinel Lymph Node Biopsy / methods | - |
dc.subject.MESH | Sentinel Lymph Node* / diagnostic imaging | - |
dc.subject.MESH | Sentinel Lymph Node* / pathology | - |
dc.subject.MESH | Sentinel Lymph Node* / surgery | - |
dc.title | Usefulness and potential pitfalls of pre-operative PET-CT in patients with endometrial cancer undergoing one- and two-step sentinel lymph node mapping: Do negative findings on PET-CT negativity really indicate node negativity? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학교실) | - |
dc.contributor.googleauthor | Yoo-Na Kim | - |
dc.contributor.googleauthor | Dahye Lee | - |
dc.contributor.googleauthor | Jongtae Cha | - |
dc.contributor.googleauthor | Won Jun Kang | - |
dc.contributor.googleauthor | Yong Jae Lee | - |
dc.contributor.googleauthor | Jung-Yun Lee | - |
dc.contributor.googleauthor | Eun Ji Nam | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Young Tae Kim | - |
dc.contributor.googleauthor | Sang Wun Kim | - |
dc.identifier.doi | 10.1016/j.ygyno.2022.07.015 | - |
dc.contributor.localId | A00062 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A01262 | - |
dc.contributor.localId | A04638 | - |
dc.contributor.localId | A00526 | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A05165 | - |
dc.relation.journalcode | J00956 | - |
dc.identifier.eissn | 1095-6859 | - |
dc.identifier.pmid | 35907682 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0090825822004875?via%3Dihub | - |
dc.subject.keyword | Endometrial neoplasms | - |
dc.subject.keyword | Lymphatic metastasis | - |
dc.subject.keyword | Positron emission tomography-computed tomography | - |
dc.subject.keyword | Sentinel lymph node biopsy | - |
dc.contributor.alternativeName | Kang, Won Jun | - |
dc.contributor.affiliatedAuthor | 강원준 | - |
dc.contributor.affiliatedAuthor | 김영태 | - |
dc.contributor.affiliatedAuthor | 남은지 | - |
dc.contributor.affiliatedAuthor | 이정윤 | - |
dc.contributor.affiliatedAuthor | 김상운 | - |
dc.contributor.affiliatedAuthor | 김성훈 | - |
dc.contributor.affiliatedAuthor | 이용재 | - |
dc.citation.volume | 166 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 438 | - |
dc.citation.endPage | 443 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC ONCOLOGY, Vol.166(3) : 438-443, 2022-09 | - |
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