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Differences in complication patterns in subgroups of type 2 diabetes according to insulin resistance and beta-cell function
DC Field | Value | Language |
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dc.contributor.author | 이용호 | - |
dc.contributor.author | 박석원 | - |
dc.date.accessioned | 2022-12-22T02:27:40Z | - |
dc.date.available | 2022-12-22T02:27:40Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/191593 | - |
dc.description.abstract | This study aimed to determine whether the patterns of diabetic complications differed when patients with type 2 diabetes mellitus (T2DM) were simply classified according to insulin sensitivity and beta-cell function. This observational study included 8861 patients with T2DM who underwent concurrent testing for fasting glucose, fasting insulin, and one or more diabetic complications. We categorized the patients into four groups according to insulin sensitivity and beta-cell function. Compared with the reference group (mild insulin resistance and beta-cell dysfunction), the "severe beta-cell dysfunction" group had lower odds of chronic kidney disease [adjusted odds ratios (aOR) 0.611]. The "severe insulin resistance" group had higher odds of carotid artery plaque presence (aOR 1.238). The "severe insulin resistance and beta-cell dysfunction" group had significantly higher odds of large fiber neuropathy (aOR 1.397, all p < 0.05). After a median of five years of follow-up, this group distinction did not lead to a difference in risk of new diabetic retinopathy or chronic kidney disease. In addition, there was no significant difference among the groups in plaque progression risk over 8-10 years in the longitudinal follow-up analysis. The patterns of complications differ when patients with T2DM are classified according to insulin resistance and beta-cell dysfunction. However, there were no differences in the risk of developing new complications. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / complications | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin | - |
dc.subject.MESH | Insulin Resistance* / physiology | - |
dc.subject.MESH | Insulin-Secreting Cells* | - |
dc.subject.MESH | Renal Insufficiency, Chronic* / complications | - |
dc.title | Differences in complication patterns in subgroups of type 2 diabetes according to insulin resistance and beta-cell function | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yongin Cho | - |
dc.contributor.googleauthor | Seong Ha Seo | - |
dc.contributor.googleauthor | Da Hea Seo | - |
dc.contributor.googleauthor | Seong Hee Ahn | - |
dc.contributor.googleauthor | Seongbin Hong | - |
dc.contributor.googleauthor | Byung Wook Huh | - |
dc.contributor.googleauthor | Yong-Ho Lee | - |
dc.contributor.googleauthor | Seok Won Park | - |
dc.contributor.googleauthor | Young Ju Suh | - |
dc.contributor.googleauthor | So Hun Kim | - |
dc.identifier.doi | 10.1038/s41598-022-13084-6 | - |
dc.contributor.localId | A02989 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 35672344 | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | 이용호 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9384 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.12(1) : 9384, 2022-06 | - |
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