Cited 109 times in
Predictors of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion
DC Field | Value | Language |
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dc.contributor.author | 김중선 | - |
dc.contributor.author | 이오현 | - |
dc.date.accessioned | 2022-11-24T00:38:26Z | - |
dc.date.available | 2022-11-24T00:38:26Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190849 | - |
dc.description.abstract | Background: Device-related thrombus (DRT) has been considered an Achilles' heel of left atrial appendage occlusion (LAAO). However, data on DRT prediction remain limited. Objectives: This study constructed a DRT registry via a multicenter collaboration aimed to assess outcomes and predictors of DRT. Methods: Thirty-seven international centers contributed LAAO cases with and without DRT (device-matched and temporally related to the DRT cases). This study described the management patterns and mid-term outcomes of DRT and assessed patient and procedural predictors of DRT. Results: A total of 711 patients (237 with and 474 without DRT) were included. Follow-up duration was similar in the DRT and no-DRT groups, median 1.8 years (interquartile range: 0.9-3.0 years) versus 1.6 years (interquartile range: 1.0-2.9 years), respectively (P = 0.76). DRTs were detected between days 0 to 45, 45 to 180, 180 to 365, and >365 in 24.9%, 38.8%, 16.0%, and 20.3% of patients. DRT presence was associated with a higher risk of the composite endpoint of death, ischemic stroke, or systemic embolization (HR: 2.37; 95% CI, 1.58-3.56; P < 0.001) driven by ischemic stroke (HR: 3.49; 95% CI: 1.35-9.00; P = 0.01). At last known follow-up, 25.3% of patients had DRT. Discharge medications after LAAO did not have an impact on DRT. Multivariable analysis identified 5 DRT risk factors: hypercoagulability disorder (odds ratio [OR]: 17.50; 95% CI: 3.39-90.45), pericardial effusion (OR: 13.45; 95% CI: 1.46-123.52), renal insufficiency (OR: 4.02; 95% CI: 1.22-13.25), implantation depth >10 mm from the pulmonary vein limbus (OR: 2.41; 95% CI: 1.57-3.69), and non-paroxysmal atrial fibrillation (OR: 1.90; 95% CI: 1.22-2.97). Following conversion to risk factor points, patients with ≥2 risk points for DRT had a 2.1-fold increased risk of DRT compared with those without any risk factors. Conclusions: DRT after LAAO is associated with ischemic events. Patient- and procedure-specific factors are associated with the risk of DRT and may aid in risk stratification of patients referred for LAAO. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier Biomedical | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Atrial Appendage / diagnostic imaging | - |
dc.subject.MESH | Atrial Appendage / surgery* | - |
dc.subject.MESH | Atrial Fibrillation / surgery* | - |
dc.subject.MESH | Cardiac Catheterization / adverse effects* | - |
dc.subject.MESH | Echocardiography, Transesophageal | - |
dc.subject.MESH | Europe / epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Heart Diseases / diagnosis | - |
dc.subject.MESH | Heart Diseases / epidemiology | - |
dc.subject.MESH | Heart Diseases / etiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Postoperative Complications / diagnosis | - |
dc.subject.MESH | Postoperative Complications / epidemiology | - |
dc.subject.MESH | Postoperative Complications / etiology* | - |
dc.subject.MESH | Registries* | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Septal Occluder Device / adverse effects* | - |
dc.subject.MESH | Survival Rate / trends | - |
dc.subject.MESH | Thrombosis / diagnosis | - |
dc.subject.MESH | Thrombosis / epidemiology | - |
dc.subject.MESH | Thrombosis / etiology* | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Predictors of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Trevor Simard | - |
dc.contributor.googleauthor | Richard G Jung | - |
dc.contributor.googleauthor | Kyle Lehenbauer | - |
dc.contributor.googleauthor | Kerstin Piayda | - |
dc.contributor.googleauthor | Radoslaw Pracoń | - |
dc.contributor.googleauthor | Gregory G Jackson | - |
dc.contributor.googleauthor | Eduardo Flores-Umanzor | - |
dc.contributor.googleauthor | Laurent Faroux | - |
dc.contributor.googleauthor | Kasper Korsholm | - |
dc.contributor.googleauthor | Julian K R Chun | - |
dc.contributor.googleauthor | Shaojie Chen | - |
dc.contributor.googleauthor | Moniek Maarse | - |
dc.contributor.googleauthor | Kristi Montrella | - |
dc.contributor.googleauthor | Zakeih Chaker | - |
dc.contributor.googleauthor | Jocelyn N Spoon | - |
dc.contributor.googleauthor | Luigi E Pastormerlo | - |
dc.contributor.googleauthor | Felix Meincke | - |
dc.contributor.googleauthor | Abhishek C Sawant | - |
dc.contributor.googleauthor | Carmen M Moldovan | - |
dc.contributor.googleauthor | Mohammed Qintar | - |
dc.contributor.googleauthor | Mehmet K Aktas | - |
dc.contributor.googleauthor | Luca Branca | - |
dc.contributor.googleauthor | Andrea Radinovic | - |
dc.contributor.googleauthor | Pradhum Ram | - |
dc.contributor.googleauthor | Rayan S El-Zein | - |
dc.contributor.googleauthor | Thomas Flautt | - |
dc.contributor.googleauthor | Wern Yew Ding | - |
dc.contributor.googleauthor | Bassel Sayegh | - |
dc.contributor.googleauthor | Tomás Benito-González | - |
dc.contributor.googleauthor | Oh-Hyun Lee | - |
dc.contributor.googleauthor | Solomon O Badejoko | - |
dc.contributor.googleauthor | Christina Paitazoglou | - |
dc.contributor.googleauthor | Nabeela Karim | - |
dc.contributor.googleauthor | Ahmed M Zaghloul | - |
dc.contributor.googleauthor | Himanshu Agrawal | - |
dc.contributor.googleauthor | Rachel M Kaplan | - |
dc.contributor.googleauthor | Oluseun Alli | - |
dc.contributor.googleauthor | Aamir Ahmed | - |
dc.contributor.googleauthor | Hussam S Suradi | - |
dc.contributor.googleauthor | Bradley P Knight | - |
dc.contributor.googleauthor | Venkata M Alla | - |
dc.contributor.googleauthor | Sidakpal S Panaich | - |
dc.contributor.googleauthor | Tom Wong | - |
dc.contributor.googleauthor | Martin W Bergmann | - |
dc.contributor.googleauthor | Rashaad Chothia | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Armando Pérez de Prado | - |
dc.contributor.googleauthor | Raveen Bazaz | - |
dc.contributor.googleauthor | Dhiraj Gupta | - |
dc.contributor.googleauthor | Miguel Valderrabano | - |
dc.contributor.googleauthor | Carlos E Sanchez | - |
dc.contributor.googleauthor | Mikhael F El Chami | - |
dc.contributor.googleauthor | Patrizio Mazzone | - |
dc.contributor.googleauthor | Marianna Adamo | - |
dc.contributor.googleauthor | Fred Ling | - |
dc.contributor.googleauthor | Dee Dee Wang | - |
dc.contributor.googleauthor | William O'Neill | - |
dc.contributor.googleauthor | Wojtek Wojakowski | - |
dc.contributor.googleauthor | Ashish Pershad | - |
dc.contributor.googleauthor | Sergio Berti | - |
dc.contributor.googleauthor | Daniel Spoon | - |
dc.contributor.googleauthor | Akram Kawsara | - |
dc.contributor.googleauthor | George Jabbour | - |
dc.contributor.googleauthor | Lucas V A Boersma | - |
dc.contributor.googleauthor | Boris Schmidt | - |
dc.contributor.googleauthor | Jens Erik Nielsen-Kudsk | - |
dc.contributor.googleauthor | Josep Rodés-Cabau | - |
dc.contributor.googleauthor | Xavier Freixa | - |
dc.contributor.googleauthor | Christopher R Ellis | - |
dc.contributor.googleauthor | Laurent Fauchier | - |
dc.contributor.googleauthor | Marcin Demkow | - |
dc.contributor.googleauthor | Horst Sievert | - |
dc.contributor.googleauthor | Michael L Main | - |
dc.contributor.googleauthor | Benjamin Hibbert | - |
dc.contributor.googleauthor | David R Holmes Jr | - |
dc.contributor.googleauthor | Mohamad Alkhouli | - |
dc.identifier.doi | 10.1016/j.jacc.2021.04.098 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A05164 | - |
dc.relation.journalcode | J01770 | - |
dc.identifier.eissn | 1558-3597 | - |
dc.identifier.pmid | 34294267 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0735109721051767 | - |
dc.subject.keyword | ACP | - |
dc.subject.keyword | Amplatzer cardiac plug | - |
dc.subject.keyword | Amulet | - |
dc.subject.keyword | DRT | - |
dc.subject.keyword | LAAO | - |
dc.subject.keyword | Watchman | - |
dc.subject.keyword | Watchman FLX | - |
dc.subject.keyword | device-related thrombus | - |
dc.subject.keyword | left atrial appendage occlusion | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | 김중선 | - |
dc.contributor.affiliatedAuthor | 이오현 | - |
dc.citation.volume | 78 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 297 | - |
dc.citation.endPage | 313 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol.78(4) : 297-313, 2021-07 | - |
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