Cited 2 times in
Early course of newly diagnosed moderate-to-severe ulcerative colitis in Korea: Results from a hospital-based inception cohort study (MOSAIK)
DC Field | Value | Language |
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dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2022-11-24T00:37:41Z | - |
dc.date.available | 2022-11-24T00:37:41Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/190832 | - |
dc.description.abstract | Background and aim: No inception cohort study has ever evaluated the early course of moderate-to-severe ulcerative colitis (UC) within 1 year of diagnosis in the non-Caucasian population. We aimed to investigate the early clinical course of moderate-to-severe UC patients in terms of remission, relapse, UC-related hospitalizations, colectomy, mortality, and overall use of medications. Methods: In the MOSAIK inception cohort, which is an ongoing multicenter, prospective, hospital-based, observational cohort, 354 patients with moderate-to-severe UC were followed up for 1 year. Main outcomes of UC and predictive factors for medication use over the course of 1 year were evaluated. Result: Among 354 patients, 276 (78.0%) patients were followed up for 1 year. The rates of remission, relapse, UC-related hospitalizations, and proximal disease extension were 95.3%, 39.6%, 15.2%, and 12.3%, respectively. Systemic corticosteroids, thiopurines, and biologics were administered to 61.2%, 30.4%, and 10.5% of patients, respectively, throughout 1 year. One year after, 58.2% patients experienced remission or mild endoscopic activity. Overall disease courses did not show much difference according to moderate or severe disease activity at baseline. In addition, no colectomy and mortality were observed for 1 year. Predictive factors for medication use included disease severity, disease extent, endoscopic severity, and presence of periappendiceal inflammation at baseline for corticosteroid, disease extent and initial corticosteroid use for thiopurine, and only initial corticosteroid use for biologics. Conclusion: Korean patients with moderate-to-severe UC may have more favorable early outcomes than Western patients. However, outcomes of them need to be further looked into for a longer time. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biological Products* / therapeutic use | - |
dc.subject.MESH | Colitis, Ulcerative* / diagnosis | - |
dc.subject.MESH | Colitis, Ulcerative* / epidemiology | - |
dc.subject.MESH | Colitis, Ulcerative* / mortality | - |
dc.subject.MESH | Colitis, Ulcerative* / therapy | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucocorticoids / therapeutic use | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Early course of newly diagnosed moderate-to-severe ulcerative colitis in Korea: Results from a hospital-based inception cohort study (MOSAIK) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jin Young Yoon | - |
dc.contributor.googleauthor | Jae Myung Cha | - |
dc.contributor.googleauthor | Chang Kyun Lee | - |
dc.contributor.googleauthor | Young Sook Park | - |
dc.contributor.googleauthor | Kyu Chan Huh | - |
dc.contributor.googleauthor | Jeong Eun Shin | - |
dc.contributor.googleauthor | You Sun Kim | - |
dc.contributor.googleauthor | Chang Soo Eun | - |
dc.contributor.googleauthor | Soon Man Yoon | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Young Soo Park | - |
dc.contributor.googleauthor | Byong Duk Ye | - |
dc.contributor.googleauthor | YoungJa Lee | - |
dc.contributor.googleauthor | Youngdoe Kim | - |
dc.contributor.googleauthor | Hyo Jong Kim | - |
dc.identifier.doi | 10.1111/jgh.15435 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J01417 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.identifier.pmid | 33555067 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/jgh.15435 | - |
dc.subject.keyword | MOSAIK | - |
dc.subject.keyword | natural history | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | treatment | - |
dc.subject.keyword | ulcerative colitis | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | 천재희 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2149 | - |
dc.citation.endPage | 2156 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.36(8) : 2149-2156, 2021-08 | - |
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