Cited 68 times in
Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP
DC Field | Value | Language |
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dc.contributor.author | 윤상선 | - |
dc.date.accessioned | 2022-08-16T01:34:10Z | - |
dc.date.available | 2022-08-16T01:34:10Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188953 | - |
dc.description.abstract | To address the drug-resistance of bacterial pathogens without imposing a selective survival pressure, virulence and biofilms are highly attractive targets. Here, we show that terrein, which was isolated from Aspergillus terreus, reduced virulence factors (elastase, pyocyanin, and rhamnolipid) and biofilm formation via antagonizing quorum sensing (QS) receptors without affecting Pseudomonas aeruginosa cell growth. Additionally, the effects of terrein on the production of QS signaling molecules and expression of QS-related genes were verified. Interestingly, terrein also reduced intracellular 3,5-cyclic diguanylic acid (c-di-GMP) levels by decreasing the activity of a diguanylate cyclase (DGC). Importantly, the inhibition of c-di-GMP levels by terrein was reversed by exogenous QS ligands, suggesting a regulation of c-di-GMP levels by QS; this regulation was confirmed using P. aeruginosa QS mutants. This is the first report to demonstrate a connection between QS signaling and c-di-GMP metabolism in P. aeruginosa, and terrein was identified as the first dual inhibitor of QS and c-di-GMP signaling. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aspergillus / chemistry | - |
dc.subject.MESH | Biofilms / drug effects | - |
dc.subject.MESH | Biofilms / growth & development | - |
dc.subject.MESH | Cyclic GMP / analogs & derivatives* | - |
dc.subject.MESH | Cyclic GMP / antagonists & inhibitors | - |
dc.subject.MESH | Cyclopentanes / isolation & purification | - |
dc.subject.MESH | Cyclopentanes / metabolism* | - |
dc.subject.MESH | Pseudomonas aeruginosa / drug effects* | - |
dc.subject.MESH | Pseudomonas aeruginosa / physiology* | - |
dc.subject.MESH | Quorum Sensing / drug effects* | - |
dc.subject.MESH | Virulence / drug effects | - |
dc.title | Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Bomin Kim | - |
dc.contributor.googleauthor | Ji-Su Park | - |
dc.contributor.googleauthor | Ha-Young Choi | - |
dc.contributor.googleauthor | Sang Sun Yoon | - |
dc.contributor.googleauthor | Won-Gon Kim | - |
dc.identifier.doi | 10.1038/s41598-018-26974-5 | - |
dc.contributor.localId | A02558 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 29872101 | - |
dc.contributor.alternativeName | Yoon, Sang Sun | - |
dc.contributor.affiliatedAuthor | 윤상선 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 8617 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.8(1) : 8617, 2018-06 | - |
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