Cited 5 times in
Alginate-Catechol Cross-Linking Interferes with Insulin Secretion Capacity in Isolated Murine Islet Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김유식 | - |
dc.contributor.author | 안철우 | - |
dc.date.accessioned | 2022-08-16T01:31:01Z | - |
dc.date.available | 2022-08-16T01:31:01Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188907 | - |
dc.description.abstract | Over the past three decades, human pancreatic islet isolation and transplantation techniques have developed as a routine clinical procedure for selected patients with type 1 diabetes mellitus. However, due to the donor shortage and required chronic systemic immunosuppression, the widespread application of islet transplantation is limited. To overcome these limitations, providing a physical barrier to transplanted islet cells with encapsulating biomaterial has emerged as a promising approach to enhance engraftment and promote islet survival post-transplantation. Alginate has been considered to be a reliable biomaterial, as it enhances islet survival and does not hamper hormone secretion. Alginate-catechol (Al-CA) hydrogel was reported to provide high mechanical strength and chemical stability without deformation over a wide range of pH values. In this study, we, demonstrated, for the first time in the literature, that encapsulation of murine pancreatic islet cells with Al-CA hydrogel does not induce cytotoxicity ex vivo for an extended period; however, it does markedly abate glucose-stimulated insulin secretion. Catechol should not be considered as a constituent for alginate gelation for encapsulating islet cells in the application of islet transplantation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Diabetes Association | - |
dc.relation.isPartOf | DIABETES & METABOLISM JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Alginate-Catechol Cross-Linking Interferes with Insulin Secretion Capacity in Isolated Murine Islet Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Research Institute (부설연구소) | - |
dc.contributor.googleauthor | Yu Sik Kim | - |
dc.contributor.googleauthor | Seung Woo Cho | - |
dc.contributor.googleauthor | Bomin Ko | - |
dc.contributor.googleauthor | Jisoo Shin | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.identifier.doi | 10.4093/dmj.2018.42.2.164 | - |
dc.contributor.localId | A05889 | - |
dc.contributor.localId | A02270 | - |
dc.relation.journalcode | J00720 | - |
dc.identifier.eissn | 2233-6087 | - |
dc.identifier.pmid | 29676546 | - |
dc.subject.keyword | Alginic acid | - |
dc.subject.keyword | Catechol | - |
dc.subject.keyword | Diabetes mellitus, type 1 | - |
dc.subject.keyword | Hydrogel | - |
dc.subject.keyword | Islets of Langerhans transplantation | - |
dc.contributor.alternativeName | Kim, Yu-Sik | - |
dc.contributor.affiliatedAuthor | 김유식 | - |
dc.contributor.affiliatedAuthor | 안철우 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 164 | - |
dc.citation.endPage | 168 | - |
dc.identifier.bibliographicCitation | DIABETES & METABOLISM JOURNAL, Vol.42(2) : 164-168, 2018-04 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.