Cited 1 times in
Efficacy and safety of dronedarone versus placebo in patients with atrial fibrillation stratified according to renal function: Post hoc analyses of the EURIDIS-ADONIS trials
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박희남 | - |
dc.date.accessioned | 2022-07-08T03:09:35Z | - |
dc.date.available | 2022-07-08T03:09:35Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 0160-9289 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188695 | - |
dc.description.abstract | Background: The use of antiarrhythmic drugs (AADs) in patients with chronic kidney disease (CKD) is complex because impaired renal clearance can cause increased drug levels, and risk of intolerance or adverse events. Due to the propensity for CKD to occur alongside atrial fibrillation/atrial flutter (AF/AFL), it is essential that AAD safety and efficacy are assessed for patients with CKD. Hypothesis: Dronedarone, an approved AAD, may present a suitable therapeutic option for patients with AF/AFL and concomitant CKD. Methods: EURIDIS-ADONIS (EURIDIS, NCT00259428; ADONIS, NCT00259376) were identically designed, multicenter, double-blind, parallel-group trials investigating AF/AFL control with dronedarone 400 mg twice daily versus placebo (randomized 2:1). In this post hoc analysis, the primary endpoint was time to first AF/AFL. Patients were stratified according to renal function using the CKD-Epidemiology Collaboration equation and divided into estimated glomerular filtration rate (eGFR) subgroups of 30-44, 45-59, 60-89, and ≥90 ml/min. Time-to-events between treatment groups were compared using log-rank testing and Cox regression. Results: At baseline, most (86%) patients demonstrated a mild or mild-to-moderate eGFR decrease. Median time to first AF/AFL recurrence was significantly longer with dronedarone versus placebo for all eGFR subgroups except the 30 to 44 ml/min group, where the trend was similar but statistical power may have been limited by the small population. eGFR stratification had no significant effect on serious adverse events, deaths, or treatment discontinuations. Conclusions: This analysis suggests that dronedarone could be an effective therapeutic option for AF with an acceptable safety profile in patients with impaired renal function. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | John Wiley & Sons, Inc. | - |
dc.relation.isPartOf | CLINICAL CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adonis* | - |
dc.subject.MESH | Amiodarone* / adverse effects | - |
dc.subject.MESH | Anti-Arrhythmia Agents / adverse effects | - |
dc.subject.MESH | Atrial Fibrillation* / complications | - |
dc.subject.MESH | Atrial Fibrillation* / diagnosis | - |
dc.subject.MESH | Atrial Fibrillation* / drug therapy | - |
dc.subject.MESH | Atrial Flutter* / drug therapy | - |
dc.subject.MESH | Dronedarone | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney / physiology | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Efficacy and safety of dronedarone versus placebo in patients with atrial fibrillation stratified according to renal function: Post hoc analyses of the EURIDIS-ADONIS trials | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Munveer Thind | - |
dc.contributor.googleauthor | Wojciech Zareba | - |
dc.contributor.googleauthor | Dan Atar | - |
dc.contributor.googleauthor | Harry J G M Crijns | - |
dc.contributor.googleauthor | Jun Zhu | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.contributor.googleauthor | James Reiffel | - |
dc.contributor.googleauthor | Ulf Ludwigs | - |
dc.contributor.googleauthor | Mattias Wieloch | - |
dc.contributor.googleauthor | John Stewart | - |
dc.contributor.googleauthor | Peter Kowey | - |
dc.identifier.doi | 10.1002/clc.23765 | - |
dc.contributor.localId | A01776 | - |
dc.relation.journalcode | J00565 | - |
dc.identifier.eissn | 1932-8737 | - |
dc.identifier.pmid | 35019175 | - |
dc.subject.keyword | antiarrhythmic drugs | - |
dc.subject.keyword | atrial fibrillation/atrial flutter | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | dronedarone | - |
dc.subject.keyword | renal function | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | 박희남 | - |
dc.citation.volume | 45 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 109 | - |
dc.identifier.bibliographicCitation | CLINICAL CARDIOLOGY, Vol.45(1) : 101-109, 2022-01 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.