Cited 55 times in
Reactivity Differences Enable ROS for Selective Ablation of Bacteria
DC Field | Value | Language |
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dc.contributor.author | 남기택 | - |
dc.date.accessioned | 2022-05-09T17:18:19Z | - |
dc.date.available | 2022-05-09T17:18:19Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188498 | - |
dc.description.abstract | An effective strategy to engineer selective photodynamic agents to surmount bacterial-infected diseases, especially Gram-positive bacteria remains a great challenge. Herein, we developed two examples of compounds for a proof-of-concept study where reactive differences in reactive oxygen species (ROS) can induce selective ablation of Gram-positive bacteria. Sulfur-replaced phenoxazinium (NBS-N) mainly generates a superoxide anion radical capable of selectively killing Gram-positive bacteria, while selenium-substituted phenoxazinium (NBSe-N) has a higher generation of singlet oxygen that can kill both Gram-positive and Gram-negative bacteria. This difference was further evidenced by bacterial fluorescence imaging and morphological changes. Moreover, NBS-N can also successfully heal the Gram-positive bacteria-infected wounds in mice. We believe that such reactive differences may pave a general way to design selective photodynamic agents for ablating Gram-positive bacteria-infected diseases. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isPartOf | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Bacterial Agents / pharmacology | - |
dc.subject.MESH | Bacteria | - |
dc.subject.MESH | Gram-Negative Bacteria | - |
dc.subject.MESH | Gram-Positive Bacteria* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Photochemotherapy* / methods | - |
dc.subject.MESH | Photosensitizing Agents / pharmacology | - |
dc.subject.MESH | Reactive Oxygen Species | - |
dc.title | Reactivity Differences Enable ROS for Selective Ablation of Bacteria | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Xiaofeng Wu | - |
dc.contributor.googleauthor | Mengyao Yang | - |
dc.contributor.googleauthor | Ji Seon Kim | - |
dc.contributor.googleauthor | Rui Wang | - |
dc.contributor.googleauthor | Gyoungmi Kim | - |
dc.contributor.googleauthor | Jeongsun Ha | - |
dc.contributor.googleauthor | Heejeong Kim | - |
dc.contributor.googleauthor | Yejin Cho | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.contributor.googleauthor | Juyoung Yoon | - |
dc.identifier.doi | 10.1002/anie.202200808 | - |
dc.contributor.localId | A01243 | - |
dc.relation.journalcode | J00147 | - |
dc.identifier.eissn | 1521-3773 | - |
dc.identifier.pmid | 35174598 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/anie.202200808 | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.affiliatedAuthor | 남기택 | - |
dc.citation.volume | 61 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | e202200808 | - |
dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol.61(17) : e202200808, 2022-04 | - |
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