Cited 6 times in
Soluble RAGE attenuates Ang II-induced arterial calcification via inhibiting AT1R-HMGB1-RAGE axis
DC Field | Value | Language |
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dc.contributor.author | 박성하 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 서미란 | - |
dc.date.accessioned | 2022-05-09T17:08:36Z | - |
dc.date.available | 2022-05-09T17:08:36Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188402 | - |
dc.description.abstract | Background and aims: Arterial calcification (AC), which is an important process in the pathogenesis of atherosclerosis, is accelerated by angiotensin II (Ang II), a critical effector of the renin-angiotensin system (RAS). Receptor for advanced glycation end-product (RAGE) is an important pattern recognition receptor downstream of Ang II. Although recent studies have suggested an association between RAGE-mediated signaling and RAS in AC, the detailed mechanism, particularly in relation to Ang II, remains unclear. Methods: Therefore, we investigated the role of RAGE-mediated signaling pathways and the therapeutic efficacy of soluble RAGE (sRAGE) in Ang II-induced AC, using both a human aortic smooth muscle cell (HAoSMC) model, and an in vivo apolipoprotein E knockout (ApoE KO) mouse model. Results: According to our data, Ang II significantly increased the calcification of HAoSMCs, and the associated activation of RAGE was mediated by subsequent HMGB1 release through Angiotensin II type 1 receptor activation. Both HMGB1 neutralizing antibody and sRAGE inhibited Ang II-induced calcium deposition. Furthermore, sRAGE attenuated HMGB1 secretion and the activation of RAGE-mediated signaling. The in vivo study indicated that Ang II significantly induced calcium deposition in the aorta, and this was significantly attenuated by sRAGE. Conclusions: Our findings strongly suggest that blockade of RAGE, using sRAGE, effectively attenuates Ang II-induced arterial calcification. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Soluble RAGE attenuates Ang II-induced arterial calcification via inhibiting AT1R-HMGB1-RAGE axis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jisu Jeong | - |
dc.contributor.googleauthor | Soyoung Cho | - |
dc.contributor.googleauthor | Miran Seo | - |
dc.contributor.googleauthor | Bok-Sim Lee | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Soyeon Lim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2022.02.022 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 35278873 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0021915022001022 | - |
dc.subject.keyword | Angiotensin II type 1 receptor (AT1R) | - |
dc.subject.keyword | Arterial calcification | - |
dc.subject.keyword | RAGE | - |
dc.subject.keyword | Soluble RAGE | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.citation.volume | 346 | - |
dc.citation.startPage | 53 | - |
dc.citation.endPage | 62 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.346 : 53-62, 2022-04 | - |
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