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The triglyceride-glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance
DC Field | Value | Language |
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dc.contributor.author | 이용제 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2022-05-09T16:48:21Z | - |
dc.date.available | 2022-05-09T16:48:21Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/188207 | - |
dc.description.abstract | Aims: Insulin resistance is an independent risk factor for developing type 2 diabetes. Therefore, this study compared the predictability of the triglyceride-glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) for the prevalence and incidence of type 2 diabetes. Methods: We analyzed data from 9730 adults aged 40-69 years at baseline and 7783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey. From 2001 to 2002 (baseline survey) to 2013-2014, this survey was conducted biennially (six follow-ups). The average follow-up period was 9.0 years. Results: The TyG index showed better predictability for the prevalence of type 2 diabetes than HOMA-IR (TyG index: 0.784, HOMA-IR: 0.728, p < 0.001). The area under the time-dependent receiver operating characteristic curve of the TyG index for incident type 2 diabetes was 0.640 (0.628-0.652), which was significantly higher than that of HOMA-IR [0.531 (0.521-0.541)] (p < 0.001). Conclusions: The TyG index is superior to HOMA-IR for predicting type 2 diabetes. The TyG index could, therefore, be more useful for the early detection and prevention of type 2 diabetes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / epidemiology | - |
dc.subject.MESH | Glucose | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Insulin Resistance* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Triglycerides | - |
dc.title | The triglyceride-glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Hye Min Park | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.contributor.googleauthor | Jun-Hyuk Lee | - |
dc.identifier.doi | 10.1016/j.diabres.2021.109042 | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 34506839 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168822721004010 | - |
dc.subject.keyword | HOMA-IR | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | TyG index | - |
dc.subject.keyword | Type 2 diabetes | - |
dc.contributor.alternativeName | Lee, Yong Jae | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 180 | - |
dc.citation.startPage | 109042 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.180 : 109042, 2021-10 | - |
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