Cited 4 times in
Intellectual Functioning of Pediatric Patients with Chronic Kidney Disease: Results from the KNOW-Ped CKD
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2022-01-26T01:55:20Z | - |
dc.date.available | 2022-01-26T01:55:20Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187380 | - |
dc.description.abstract | Background: Chronic kidney disease (CKD) has a negative impact on growth and development in children and is a risk factor for neurocognitive impairment; however, there is limited research on the cognitive function of children and adolescents with CKD. This study therefore aimed to investigate the mean intelligence and risk factors for low intelligence in children and adolescents with CKD. Methods: Eighty-one patients with CKD under 18 years old were included in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD). Participants completed either the Wechsler Intelligence Scale for Children (6-16 years), or Wechsler Adult Intelligence Scale (> 16 years). Results: The mean full-scale intelligence quotient (IQ) was 91 ± 19; 24.7% of participants scored a full-scale IQ below 80. Participants with a short stature (height Z scores < -1.88), failure to thrive (weight Z scores < -1.65), more severe CKD stage (≥ IIIb), longer duration of CKD (≥ 5 years), and those who were Medicare or Medicaid beneficiaries, had significantly lower mean full-scale IQs. Conclusion: On linear regression analysis, the association between the full-scale IQ, and longer duration of CKD and growth failure, remained significant after controlling for demographic and clinical variables. It is therefore necessary to investigate cognitive impairment in pediatric patients with CKD who exhibit growth failure or for a longer postmorbid period. It is believed that early interventions, such as kidney transplantation, will have a positive effect on IQ in children with CKD, as the disease negatively affects IQ due to poor glomerular filtration rate over time. Trial registration: ClinicalTrials.gov Identifier: NCT02165878. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Cognition / physiology* | - |
dc.subject.MESH | Cognition Disorders / diagnosis | - |
dc.subject.MESH | Cognition Disorders / epidemiology* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intelligence Tests | - |
dc.subject.MESH | Intelligence* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Quality of Life* | - |
dc.subject.MESH | Renal Insufficiency, Chronic / epidemiology* | - |
dc.subject.MESH | Renal Insufficiency, Chronic / psychology* | - |
dc.title | Intellectual Functioning of Pediatric Patients with Chronic Kidney Disease: Results from the KNOW-Ped CKD | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Na Ri Kang | - |
dc.contributor.googleauthor | Yo Han Ahn | - |
dc.contributor.googleauthor | Eujin Park | - |
dc.contributor.googleauthor | Keum Hwa Lee | - |
dc.contributor.googleauthor | Hee Sun Baek | - |
dc.contributor.googleauthor | Seong Heon Kim | - |
dc.contributor.googleauthor | Heeyeon Cho | - |
dc.contributor.googleauthor | Min Hyun Cho | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Joo Hoon Lee | - |
dc.contributor.googleauthor | Hae Il Cheong | - |
dc.contributor.googleauthor | Hee Gyung Kang | - |
dc.contributor.googleauthor | Young Seo Park | - |
dc.contributor.googleauthor | Il Soo Ha | - |
dc.contributor.googleauthor | Duk Soo Moon | - |
dc.contributor.googleauthor | Kyoung Hee Han | - |
dc.identifier.doi | 10.3346/jkms.2021.36.e138 | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 34032031 | - |
dc.subject.keyword | Children | - |
dc.subject.keyword | Chronic Kidney Disease | - |
dc.subject.keyword | Intelligence | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | e138 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.36(20) : e138, 2021-05 | - |
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