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Effects of Perioperative Dexmedetomidine on Immunomodulation in Uterine Cancer Surgery: A Randomized, Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | 김상운 | - |
dc.contributor.author | 유영철 | - |
dc.contributor.author | 조진선 | - |
dc.date.accessioned | 2021-12-28T17:42:04Z | - |
dc.date.available | 2021-12-28T17:42:04Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187229 | - |
dc.description.abstract | Objective: Dexmedetomidine has sympatholytic, anti-inflammatory, and analgesic effects and may exert anti-tumor effect by acting on α2A adrenoreceptor. We investigated whether perioperative dexmedetomidine preserves immune function in patients undergoing uterine cancer surgery. Methods: One hundred patients were randomly assigned to the control or dexmedetomidine groups (50 patients each). Dexmedetomidine was infused at rates of 0.4 μg/kg/h intraoperatively and 0.15 μg/kg/h during the first 24 h postoperatively. The primary outcome was natural killer (NK) cell activity, which was measured preoperatively and 1, 3, and 5 days postoperatively. The inflammatory response was measured by interleukin-6, interferon-γ, and neutrophil/lymphocyte ratio, and pain scores and opioid consumption were assessed. Cancer recurrence or metastasis and death were evaluated 2 years postoperatively. Results: NK cell activity decreased postoperatively in both groups and changes over time were not different between groups (P=0.496). Interferon-γ increased postoperatively in the dexmedetomidine group, whereas it maintained at the baseline value in the control group. Change in interferon-γ differed significantly between groups (P=0.003). Changes in interleukin-6 and neutrophil-lymphocyte ratio were comparable between groups. Both pain score with activity during the first 1 h and opioid consumption during the first 1-24 h postoperatively were lower in the dexmedetomidine group. Rates of cancer recurrence/metastasis (16.3% vs. 8.7%, P=0.227) and death within 2 years postoperatively (6.7% vs. 2.2%, P=0.318) were not different between groups. Conclusions: Perioperative dexmedetomidine had no favorable impacts on NK cell activity, inflammatory responses, or prognosis, whereas it increased interferon-γ and reduced early postoperative pain severity and opioid consumption in uterine cancer surgery patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effects of Perioperative Dexmedetomidine on Immunomodulation in Uterine Cancer Surgery: A Randomized, Controlled Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | Jin Sun Cho | - |
dc.contributor.googleauthor | Kieun Seon | - |
dc.contributor.googleauthor | Min-Yu Kim | - |
dc.contributor.googleauthor | Sang Wun Kim | - |
dc.contributor.googleauthor | Young Chul Yoo | - |
dc.identifier.doi | 10.3389/fonc.2021.749003 | - |
dc.contributor.localId | A00526 | - |
dc.contributor.localId | A02484 | - |
dc.contributor.localId | A03914 | - |
dc.relation.journalcode | J03512 | - |
dc.identifier.eissn | 2234-943X | - |
dc.identifier.pmid | 34868950 | - |
dc.subject.keyword | dexmedetomidine | - |
dc.subject.keyword | immunity | - |
dc.subject.keyword | interferon-γ | - |
dc.subject.keyword | natural killer cell | - |
dc.subject.keyword | uterine cancer | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.affiliatedAuthor | 김상운 | - |
dc.contributor.affiliatedAuthor | 유영철 | - |
dc.contributor.affiliatedAuthor | 조진선 | - |
dc.citation.volume | 11 | - |
dc.citation.startPage | 749003 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN ONCOLOGY, Vol.11 : 749003, 2021-11 | - |
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