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The paradoxical response to short-acting bronchodilator administration in patients with chronic obstructive pulmonary disease
DC Field | Value | Language |
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dc.contributor.author | 변민광 | - |
dc.date.accessioned | 2021-12-28T17:14:17Z | - |
dc.date.available | 2021-12-28T17:14:17Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 2072-1439 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186999 | - |
dc.description.abstract | Background: There are a few studies about paradoxical bronchodilator response (BDR), which means a decrease in forced expiratory volume in 1 second (FEV1) or forced vital capacity (FVC) after short-acting bronchodilator administration in patients with chronic obstructive pulmonary disease (COPD). We evaluated the effect of paradoxical BDR on the clinical outcomes of COPD patients in South Korea. Methods: We analyzed the KOrea COpd Subgroup Study team (KOCOSS) cohort data in South Korea between January 2012 and December 2017. BDR was defined as at least a 12% and 200-mL reduction in FEV1 or FVC after bronchodilator administration. Results: A total of 1,991 patients were included in this study. A paradoxical BDR was noted in 57 (2.9%) patients and was independently associated with worse dyspnea and poor quality of life. High C-reactive protein (CRP) levels were associated with a paradoxical BDR (OR, 1.05; 95% CI, 1.01-1.09; P=0.003). However, paradoxical BDR was not associated with severe acute exacerbations. Pre-bronchodilator FEV1 (L) showed a higher area under the curve (AUC) for predicting severe acute exacerbations than the post-bronchodilator FEV1 (L) in the paradoxical BDR group (0.788 vs. 0.752). Conclusion: A paradoxical reduction of FEV1 or FVC after bronchodilator administration may be associated with chronic inflammation in the airway and independently associated with worse respiratory symptoms and poor quality of life. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Pioneer Bioscience Pub. Co. | - |
dc.relation.isPartOf | JOURNAL OF THORACIC DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The paradoxical response to short-acting bronchodilator administration in patients with chronic obstructive pulmonary disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hong-Joon Shin | - |
dc.contributor.googleauthor | Tae-Ok Kim | - |
dc.contributor.googleauthor | Yu-Il Kim | - |
dc.contributor.googleauthor | Sang-Hoon Kim | - |
dc.contributor.googleauthor | Hyun Kuk Kim | - |
dc.contributor.googleauthor | Yong-Hyun Kim | - |
dc.contributor.googleauthor | Min Kwang Byun | - |
dc.contributor.googleauthor | Ki-Suck Jung | - |
dc.contributor.googleauthor | Kwang-Ha Yoo | - |
dc.contributor.googleauthor | Jae Seung Lee | - |
dc.contributor.googleauthor | Sung-Chul Lim | - |
dc.identifier.doi | 10.21037/jtd-20-985 | - |
dc.contributor.localId | A01848 | - |
dc.relation.journalcode | J01907 | - |
dc.identifier.eissn | 2077-6624 | - |
dc.identifier.pmid | 33717524 | - |
dc.subject.keyword | Bronchodilator | - |
dc.subject.keyword | C-reactive protein (CRP) | - |
dc.subject.keyword | chronic obstructive pulmonary disease (COPD) | - |
dc.subject.keyword | exacerbation | - |
dc.subject.keyword | paradoxical | - |
dc.contributor.alternativeName | Byun, Min Kwang | - |
dc.contributor.affiliatedAuthor | 변민광 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 511 | - |
dc.citation.endPage | 520 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THORACIC DISEASE, Vol.13(2) : 511-520, 2021-02 | - |
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