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Peri-operative Inflammatory Marker as a Predictive Factor for Prolonged Post-operative Ileus After Gastrectomy for Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | 김지현 | - |
dc.contributor.author | 박효진 | - |
dc.contributor.author | 윤영훈 | - |
dc.contributor.author | 김종원 | - |
dc.contributor.author | 김영민 | - |
dc.date.accessioned | 2021-12-28T17:02:38Z | - |
dc.date.available | 2021-12-28T17:02:38Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 2093-0879 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186908 | - |
dc.description.abstract | Background/aims: Although prolonged post-operative ileus (PPOI) is an important factor for the prolonged length of post-operative hospital stay, there is still a lack of effective predictive and therapeutic methods for PPOI. Previous studies reported that increased inflammatory markers, such as C-reactive protein (CRP) level and neutrophil to lymphocyte ratio (NLR), are associated with malignancies. The aim of our study is to elucidate the association between peri-operative inflammatory markers and PPOI after gastrectomy for gastric cancer. Methods: We enrolled patients who received gastrectomy for gastric cancer from June 2013 to January 2016 at a single tertiary referral center in Seoul, Korea. We evaluated peri-operative inflammatory markers, including CRP level, NLR, and platelet to lymphocyte ratio (PLR) of enrolled patients. We compared these data between control group and PPOI group. Results: A total of 390 subjects were enrolled in this study, and 132 patients (33.8%) showed PPOI. In univariate analysis, preoperative CRP level and NLR, post-operative day (POD) 1 CRP level, NLR, and PLR, and POD3 CRP level, NLR, and PLR were significantly associated with PPOI. In multivariate analysis, preoperative NLR (P = 0.014), POD1 NLR (P = 0.019), POD3 CRP (P = 0.004), and POD3 NLR (P = 0.008) were independent risk factors for PPOI. Conclusions: Peri-operative inflammatory markers, such as CRP level and NLR, are useful predictive factors for PPOI who received gastrectomy for gastric cancer. Moreover, prophylactic antibiotics and anti-inflammatory drugs can be preventive and therapeutic agents for PPOI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | Korean Society of Neurogastroenterology and Motility | - |
dc.relation.isPartOf | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Peri-operative Inflammatory Marker as a Predictive Factor for Prolonged Post-operative Ileus After Gastrectomy for Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yonsoo Kim | - |
dc.contributor.googleauthor | Young Min Kim | - |
dc.contributor.googleauthor | Jie-Hyun Kim | - |
dc.contributor.googleauthor | Young Hoon Youn | - |
dc.contributor.googleauthor | Jong Won Kim | - |
dc.contributor.googleauthor | Hyojin Park | - |
dc.identifier.doi | 10.5056/jnm20203 | - |
dc.contributor.localId | A00996 | - |
dc.contributor.localId | A01774 | - |
dc.contributor.localId | A02583 | - |
dc.relation.journalcode | J01623 | - |
dc.identifier.eissn | 2093-0887 | - |
dc.identifier.pmid | 34642279 | - |
dc.subject.keyword | Gastrectomy | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Post-operative ileus | - |
dc.contributor.alternativeName | Kim, Jie-Hyun | - |
dc.contributor.affiliatedAuthor | 김지현 | - |
dc.contributor.affiliatedAuthor | 박효진 | - |
dc.contributor.affiliatedAuthor | 윤영훈 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 588 | - |
dc.citation.endPage | 595 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.27(4) : 588-595, 2021-10 | - |
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