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Cyproheptadine Angmentation of Haloperidol in Chronic Schizophrenic Patients : A Double Blind Placebo-Controlled Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송동호 | - |
dc.contributor.author | 이홍식 | - |
dc.date.accessioned | 2021-12-27T17:17:48Z | - |
dc.date.available | 2021-12-27T17:17:48Z | - |
dc.date.issued | 1995-06 | - |
dc.identifier.issn | 0268-1315 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186533 | - |
dc.description.abstract | A 6 week double-blind placebo-controlled trial of cyproheptadine augmentation of ongoing haloperidol treatment was conducted in 40 chronic schizophrenic in-patients. Cyproheptadine augmentation, compared to administration of haloperidol with placebo, did not produce a statistically significant improvement in psychotic symptoms. Cyproheptadine augmentation caused significant reduction in the extrapyramidal symptoms, which supports the atypical profile of antipsychotics. As to the neuroendocrinological effect, cyproheptadine augmentation did not reduce the plasma prolactin level but did induce a decrease in the plasma cortisol level. Although long-term follow-up studies are needed to confirm the results, this study suggests that cyproheptadine augmentation may be effective in treating chronic schizophrenic patients who are intolerant of extrapyramidal side effects of conventional antipsychotics. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams And Wilkins | - |
dc.relation.isPartOf | INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Cyproheptadine / therapeutic use* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Haloperidol / therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydrocortisone / blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Placebos | - |
dc.subject.MESH | Prolactin / blood | - |
dc.subject.MESH | Schizophrenia / blood | - |
dc.subject.MESH | Schizophrenia / drug therapy* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Cyproheptadine Angmentation of Haloperidol in Chronic Schizophrenic Patients : A Double Blind Placebo-Controlled Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | H.S. Lee | - |
dc.contributor.googleauthor | D.H. Song | - |
dc.contributor.googleauthor | J.H. Kim | - |
dc.contributor.googleauthor | Y.M. Lee | - |
dc.contributor.googleauthor | E.S. Han | - |
dc.contributor.googleauthor | K.J. Yoo | - |
dc.identifier.doi | 10.1097/00004850-199506000-00002 | - |
dc.contributor.localId | A02018 | - |
dc.contributor.localId | A03332 | - |
dc.relation.journalcode | J01076 | - |
dc.identifier.eissn | 1473-5857 | - |
dc.identifier.pmid | 7673658 | - |
dc.identifier.url | https://oce.ovid.com/article/00004850-199506000-00002/HTML | - |
dc.contributor.alternativeName | Song, Dong Ho | - |
dc.contributor.affiliatedAuthor | 송동호 | - |
dc.contributor.affiliatedAuthor | 이홍식 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 67 | - |
dc.citation.endPage | 72 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, Vol.10(2) : 67-72, 1995-06 | - |
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