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Increased Risk of Chronic Kidney Disease Associated With Weight Gain in Healthy Adults: Insight From Metabolic Profiles and Body Composition
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 김형우 | - |
dc.contributor.author | 남기헌 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 윤해룡 | - |
dc.contributor.author | 주영수 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 강이화 | - |
dc.date.accessioned | 2021-11-19T01:35:36Z | - |
dc.date.available | 2021-11-19T01:35:36Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185931 | - |
dc.description.abstract | Objective: Obesity is an established risk factor for kidney damage. In this study, we explored the long-term association of changes in body mass index (BMI) over time with incident chronic kidney disease (CKD). Methods: For this analysis, 5,393 middle-aged adults without comorbidities in the Korean Genome and Epidemiology Study (KoGES) were included. Group-based trajectory modeling was used to determine the patterns of BMI change (decreasing, stable, and increasing BMI) between baseline and year 4. The primary outcome was the subsequent development of CKD from year 4. A multivariable Cox proportional hazards model was constructed to determine the risk of incident CKD according to BMI trajectories. Results: During 55,327 person-years, incident CKD occurred in 354 (6.5%) participants; 6.0, 6.1, and 7.8 per 1,000 person-years across the trajectories, respectively (P = 0.005). In the multivariable-adjusted Cox proportional hazards model, the increasing BMI trajectory was associated with a 1.4-fold [hazard ratio (HR), 1.41; 95% CI, 1.06-1.87] a higher risk of incident CKD compared with stable BMI trajectory. This association was stronger for overweight and obese individuals. The HRs for CKD development in these two groups were 1.6 (95% CI, 1.06-1.87) and 2.2 (95% CI, 1.40-3.48), respectively. While the increasing BMI group was gaining weight, there were concomitant increases in blood pressure, insulin resistance, serum concentrations of total cholesterol, triglyceride, and high-sensitivity C-reactive protein (hs-CRP), and fat mass, but high-density lipoprotein (HDL)-cholesterol level and muscle-to-fat (MF) ratio decreased. Conclusion: Weight gain is associated with an increased risk of incident CKD in healthy adults. This association is attributed to worsening metabolic profiles and increasing fat mass. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Media S.A. | - |
dc.relation.isPartOf | FRONTIERS IN MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Increased Risk of Chronic Kidney Disease Associated With Weight Gain in Healthy Adults: Insight From Metabolic Profiles and Body Composition | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hae-Ryong Yun | - |
dc.contributor.googleauthor | Hyung Woo Kim | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.contributor.googleauthor | Ea Wha Kang | - |
dc.contributor.googleauthor | Young Su Joo | - |
dc.contributor.googleauthor | Ki Heon Nam | - |
dc.contributor.googleauthor | Hyoungnae Kim | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.3389/fmed.2021.705881 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01151 | - |
dc.contributor.localId | A01244 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04617 | - |
dc.contributor.localId | A03956 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J03762 | - |
dc.identifier.eissn | 2296-858X | - |
dc.identifier.pmid | 34650992 | - |
dc.subject.keyword | body composition | - |
dc.subject.keyword | body mass index | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | group-based trajectory modeling | - |
dc.subject.keyword | metabolic profiles | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 김형우 | - |
dc.contributor.affiliatedAuthor | 남기헌 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 윤해룡 | - |
dc.contributor.affiliatedAuthor | 주영수 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 8 | - |
dc.citation.startPage | 705881 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN MEDICINE, Vol.8 : 705881, 2021-09 | - |
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