Cited 6 times in
Ovotesticular Disorder of Sex Development in Korean Children: A Single-Center Analysis over a 30-Year Period
DC Field | Value | Language |
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dc.contributor.author | 김혜인 | - |
dc.contributor.author | 윤보현 | - |
dc.contributor.author | 이용승 | - |
dc.contributor.author | 이인하 | - |
dc.contributor.author | 한상원 | - |
dc.date.accessioned | 2021-10-21T00:07:27Z | - |
dc.date.available | 2021-10-21T00:07:27Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 1083-3188 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185387 | - |
dc.description.abstract | Study objective: To present clinical features that characterize ovotesticular disorder of sex development (OT-DSD) in the Korean population. Among the patient cohort who were initially suspected to have OT-DSD, the actual OT-DSD patients and those of other disorder of sex development were compared. Design: Retrospective medical chart review of patients who were initially suspected to have OT-DSD from 1984 to 2018 on the basis of clinical examination. Setting: Tertiary care university hospital. Participants: Of 26 patients with initial diagnosis of OT-DSD, 3 were excluded because of incomplete records, and finally, 23 patients were subjected to analysis. Various examinations were performed before the surgical confirmation of gonad histopathology. Interventions: Medical records were reviewed for clinical, anatomical, biochemical, and cytogenic characteristics, gender assignment, medical treatment, and histopathologic diagnosis. Main outcome measures: Characteristics of OT-DSD in a Korean population. Results: Among 23 patients suspected to have OT-DSD, 13/23 (56.5%) were diagnosed as OT-DSD after histopathologic confirmation. Of the remaining 10 patients, 5/23 (21.7%) were diagnosed with mixed gonadal dysgenesis, 3 with Turner variant, 1 with 46,XX disorder of sex development, and 1 with Mayer-Rokitansky-Küster-Hauser syndrome. Among the 13 OT-DSD cases, 9 patients presented with the 46,XX karyotype, 1 with the 46,XY, and 3 with the 46,XX/XY karyotype. Nine patients were assigned as male and 4 as female at birth. The most common gonad histology was ovotestis 10/26 (38%), followed by ovary and testis. Conclusion: OT-DSD is one of the rarest disorders with various clinical presentations. A patient with ambiguous genitalia must be examined with a multidisciplinary approach with clinical suspicion for OT-DSD. Standardized procedure of evaluation and treatment is crucial. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Ovotesticular Disorder of Sex Development in Korean Children: A Single-Center Analysis over a 30-Year Period | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | Hye In Kim | - |
dc.contributor.googleauthor | Inha Lee | - |
dc.contributor.googleauthor | Sang Hwa Kim | - |
dc.contributor.googleauthor | Yong Seung Lee | - |
dc.contributor.googleauthor | Sang Won Han | - |
dc.contributor.googleauthor | Bo Hyon Yun | - |
dc.identifier.doi | 10.1016/j.jpag.2021.02.105 | - |
dc.contributor.localId | A05969 | - |
dc.contributor.localId | A02555 | - |
dc.contributor.localId | A02980 | - |
dc.contributor.localId | A05497 | - |
dc.contributor.localId | A04285 | - |
dc.relation.journalcode | J04118 | - |
dc.identifier.eissn | 1873-4332 | - |
dc.identifier.pmid | 33667640 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1083318821001492 | - |
dc.subject.keyword | Disorders of sex development | - |
dc.subject.keyword | Ovotesticular disorder | - |
dc.subject.keyword | True hermaphrodite | - |
dc.contributor.alternativeName | Kim, Hye In | - |
dc.contributor.affiliatedAuthor | 김혜인 | - |
dc.contributor.affiliatedAuthor | 윤보현 | - |
dc.contributor.affiliatedAuthor | 이용승 | - |
dc.contributor.affiliatedAuthor | 이인하 | - |
dc.contributor.affiliatedAuthor | 한상원 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 626 | - |
dc.citation.endPage | 630 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY, Vol.34(5) : 626-630, 2021-10 | - |
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