Cited 4 times in
Efficacy and Safety Evaluation of Human Growth Hormone Therapy in Patients with Idiopathic Short Stature in Korea - A Randomised Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | 김호성 | - |
dc.contributor.author | 김동욱 | - |
dc.contributor.author | 김진성 | - |
dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2021-09-29T02:28:52Z | - |
dc.date.available | 2021-09-29T02:28:52Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 1758-3772 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184924 | - |
dc.description.abstract | Background: This trial evaluated the efficacy and safety of growth hormone (GH) therapy (Norditropin®; Novo Nordisk, Bagsværd, Denmark) in paediatric patients with idiopathic short stature (ISS) in Korea. Methods: This was an open-label, parallel-group, multicentre, interventional trial (ClinicalTrials.gov identifier: NCT01778023). Pre-pubertal patients (mean age 6.2 years; height, 107.1 cm) were randomised 2:1 to 12 months' GH treatment (0.469 mg/kg/week; group A, n=36) or 6 months untreated followed by 6 months' GH treatment (group B, n=18). Safety analysis was based on adverse events (AEs) in all GH-treated patients. Results: After 6 months, height velocity (Ht-V), change in both height standard deviation score (Ht-SDS) and insulin-like growth factor 1 (mean difference [95% confidence interval {CI}]: 5.15 cm/year [4.09, 6.21]; 0.57 [0.43, 0.71]; 164.56 ng/mL [112.04, 217.08], respectively; all p<0.0001) were greater in group A than in group B. Mean difference in Ht-V for 0-6 months versus 6-12 months was 2.80 cm/year (95% CI 1.55, 4.04) for group A and -4.60 cm/year (95% CI -6.12, -3.09; both p<0.0001) for group B. No unexpected AEs were reported. Conclusions: During the first 6 months, height was significantly increased in GH-treated patients versus untreated patients with ISS. Safety of GH was consistent with the known safety profile. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Touch Medical Media | - |
dc.relation.isPartOf | European Endocrinology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Efficacy and Safety Evaluation of Human Growth Hormone Therapy in Patients with Idiopathic Short Stature in Korea - A Randomised Controlled Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Min Ho Jung | - |
dc.contributor.googleauthor | Byung-Kyu Suh | - |
dc.contributor.googleauthor | Cheol Woo Ko | - |
dc.contributor.googleauthor | Kee-Hyoung Lee | - |
dc.contributor.googleauthor | Dong-Kyu Jin | - |
dc.contributor.googleauthor | Han-Wook Yoo | - |
dc.contributor.googleauthor | Jin Soon Hwang | - |
dc.contributor.googleauthor | Woo Yeong Chung | - |
dc.contributor.googleauthor | Heon-Seok Han | - |
dc.contributor.googleauthor | Vinay Prusty | - |
dc.contributor.googleauthor | Ho-Seong Kim | - |
dc.identifier.doi | 10.17925/EE.2020.16.1.54 | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A05657 | - |
dc.contributor.localId | A01650 | - |
dc.contributor.localId | A05893 | - |
dc.contributor.localId | A03865 | - |
dc.contributor.localId | A03979 | - |
dc.contributor.localId | A05710 | - |
dc.contributor.localId | A04548 | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J04069 | - |
dc.identifier.eissn | 1758-3780 | - |
dc.identifier.pmid | 32595770 | - |
dc.subject.keyword | Human growth hormone | - |
dc.subject.keyword | clinical trial | - |
dc.subject.keyword | idiopathic | - |
dc.subject.keyword | short stature | - |
dc.contributor.alternativeName | Kim, Ho Seong | - |
dc.contributor.affiliatedAuthor | 김호성 | - |
dc.contributor.affiliatedAuthor | 김동욱 | - |
dc.contributor.affiliatedAuthor | 김진성 | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 54 | - |
dc.citation.endPage | 59 | - |
dc.identifier.bibliographicCitation | European Endocrinology, Vol.16(1) : 54-59, 2020-03 | - |
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