Cited 14 times in
Association Between the Risk for Cardiovascular Events and Antiviral Treatment for Herpes Zoster
DC Field | Value | Language |
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dc.contributor.author | 김진권 | - |
dc.contributor.author | 이경열 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2021-09-29T02:24:17Z | - |
dc.date.available | 2021-09-29T02:24:17Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184871 | - |
dc.description.abstract | Background: Cardiovascular risk increases following herpes zoster. We investigated whether treatment with antiviral agents, steroids, and common cardiovascular medications was associated with the risk of postherpetic cardiovascular events. Methods: This was a nationwide population-based, retrospective, cohort study using the National Health Insurance Service health claims data in Korea. We included patients with a first-ever diagnosis of herpes zoster in 2003-2014 and no prior cardiovascular event. The primary outcome was the occurrence of composites of myocardial infarction (International Statistical Classification of Diseases, Tenth Revision, code I21) and stroke (codes I60-I63) since the herpes zoster. We analyzed the exposure (intravenous or oral administration) to antiviral agents, steroids, antithrombotics, and statins within ±7 days from the index date of herpes zoster diagnosis. Follow-up was performed until occurrence of the primary outcome, death, or 31 December 2015, whichever came first. Results: Of 84 993 patients with herpes zoster, the proportions of patients who received the treatment with antiviral agents, steroids, antithrombotics, and statins were 90.5%, 48.0%, 9.1%, and 7.9%, respectively. During the mean (standard deviation) follow-up period of 5.4 (3.1) years, 1523 patients experienced the primary outcome. Multivariate Cox regression analysis demonstrated that treatment with antiviral agents (adjusted hazard ratio, 0.82; 95% confidence interval, .71-.95) and statins (0.71; .59-.85) were significantly associated with the lower risk of primary outcome. Use of antithrombotics and steroids were not associated with the risk. Conclusions: After herpes zoster, treatment with antiviral agents was significantly associated with lower risk of cardiovascular events. We need more information on the cardiovascular protective role of herpes zoster treatments. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | CLINICAL INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association Between the Risk for Cardiovascular Events and Antiviral Treatment for Herpes Zoster | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Jinkwon Kim | - |
dc.contributor.googleauthor | Jimin Jeon | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Kyung-Yul Lee | - |
dc.identifier.doi | 10.1093/cid/ciaa1384 | - |
dc.contributor.localId | A01012 | - |
dc.contributor.localId | A02648 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J00581 | - |
dc.identifier.eissn | 1537-6591 | - |
dc.identifier.pmid | 32926085 | - |
dc.identifier.url | https://academic.oup.com/cid/article/73/5/758/5905502 | - |
dc.subject.keyword | antiviral | - |
dc.subject.keyword | cardiovascular | - |
dc.subject.keyword | herpes zoster | - |
dc.subject.keyword | statin | - |
dc.subject.keyword | varicella | - |
dc.contributor.alternativeName | Kim, Jin Kwon | - |
dc.contributor.affiliatedAuthor | 김진권 | - |
dc.contributor.affiliatedAuthor | 이경열 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 73 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 758 | - |
dc.citation.endPage | 764 | - |
dc.identifier.bibliographicCitation | CLINICAL INFECTIOUS DISEASES, Vol.73(5) : 758-764, 2021-09 | - |
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