Cited 11 times in
Peripheral Nerve-Derived Stem Cell Spheroids Induce Functional Recovery and Repair after Spinal Cord Injury in Rodents
DC Field | Value | Language |
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dc.contributor.author | 김긍년 | - |
dc.contributor.author | 하윤 | - |
dc.contributor.author | 이혜영 | - |
dc.date.accessioned | 2021-09-29T01:49:38Z | - |
dc.date.available | 2021-09-29T01:49:38Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184567 | - |
dc.description.abstract | Stem cell therapy is one of the most promising candidate treatments for spinal cord injury. Research has shown optimistic results for this therapy, but clinical limitations remain, including poor viability, engraftment, and differentiation. Here, we isolated novel peripheral nerve-derived stem cells (PNSCs) from adult peripheral nerves with similar characteristics to neural-crest stem cells. These PNSCs expressed neural-crest specific markers and showed multilineage differentiation potential into Schwann cells, neuroglia, neurons, and mesodermal cells. In addition, PNSCs showed therapeutic potential by releasing the neurotrophic factors, including glial cell-line-derived neurotrophic factor, insulin-like growth factor, nerve growth factor, and neurotrophin-3. PNSC abilities were also enhanced by their development into spheroids which secreted neurotrophic factors several times more than non-spheroid PNSCs and expressed several types of extra cellular matrix. These features suggest that the potential for these PNSC spheroids can overcome their limitations. In an animal spinal cord injury (SCI) model, these PNSC spheroids induced functional recovery and neuronal regeneration. These PNSC spheroids also reduced the neuropathic pain which accompanies SCI after remyelination. These PNSC spheroids may represent a new therapeutic approach for patients suffering from SCI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Neural Stem Cells / cytology | - |
dc.subject.MESH | Neurogenesis | - |
dc.subject.MESH | Peripheral Nerves / cytology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Schwann Cells / cytology | - |
dc.subject.MESH | Spheroids, Cellular / cytology | - |
dc.subject.MESH | Spheroids, Cellular / transplantation* | - |
dc.subject.MESH | Spinal Cord Injuries / therapy* | - |
dc.subject.MESH | Spinal Cord Regeneration* | - |
dc.subject.MESH | Stem Cell Transplantation / methods* | - |
dc.title | Peripheral Nerve-Derived Stem Cell Spheroids Induce Functional Recovery and Repair after Spinal Cord Injury in Rodents | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Hye-Lan Lee | - |
dc.contributor.googleauthor | Chung-Eun Yeum | - |
dc.contributor.googleauthor | HyeYeong Lee | - |
dc.contributor.googleauthor | Jinsoo Oh | - |
dc.contributor.googleauthor | Jong-Tae Kim | - |
dc.contributor.googleauthor | Won-Jin Lee | - |
dc.contributor.googleauthor | Yoon Ha | - |
dc.contributor.googleauthor | Young-Il Yang | - |
dc.contributor.googleauthor | Keung-Nyun Kim | - |
dc.identifier.doi | 10.3390/ijms22084141 | - |
dc.contributor.localId | A00331 | - |
dc.contributor.localId | A04255 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 33923671 | - |
dc.subject.keyword | functional recovery | - |
dc.subject.keyword | neuroregeneration | - |
dc.subject.keyword | neurotrophic factor | - |
dc.subject.keyword | peripheral nerve-derived stem cells | - |
dc.subject.keyword | spheroids | - |
dc.subject.keyword | spinal cord injury | - |
dc.contributor.alternativeName | Kim, Keung Nyun | - |
dc.contributor.affiliatedAuthor | 김긍년 | - |
dc.contributor.affiliatedAuthor | 하윤 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 4141 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(8) : 4141, 2021-04 | - |
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