Cited 2 times in
Dipstick proteinuria and risk of type 2 diabetes mellitus: a nationwide population-based cohort study
DC Field | Value | Language |
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dc.contributor.author | 김진권 | - |
dc.date.accessioned | 2021-09-29T01:06:19Z | - |
dc.date.available | 2021-09-29T01:06:19Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184198 | - |
dc.description.abstract | Background: Proteinuria has been recognized as a marker of systemic inflammation and endothelial dysfunction associated with insulin resistance and β-cell impairment, which can contribute to the development of type 2 diabetes mellitus (T2DM). However, it is unknown whether the dipstick proteinuria test has a predictive value for new-onset T2DM. Methods: This retrospective cohort study analyzed 239,287 non-diabetic participants who participated in the Korean nationwide health screening program in 2009-2010. Proteinuria was determined by the urine dipstick test at the baseline health screening. We performed multivariate Cox proportional regression analyses for the development of new-onset T2DM. Follow-up was performed until December 2015. Results: During the mean follow-up period of 5.73 years, 22,215 participants were diagnosed with new-onset T2DM. The presence of proteinuria was significantly associated with an increased risk of T2DM (adjusted hazard ratio: 1.19, 95% confidence interval: 1.10, 1.29). There was a positive dose-response relationship between the degree of dipstick proteinuria and T2DM risk. This significant association between proteinuria and T2DM risk was consistent regardless of the fasting glucose level at baseline. Conclusions: Dipstick proteinuria is a significant risk factor for new-onset T2DM. Therefore, proteinuria might be a useful biomarker to identify those at a high risk for developing T2DM. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | JOURNAL OF TRANSLATIONAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / complications | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / epidemiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Proteinuria / complications | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Dipstick proteinuria and risk of type 2 diabetes mellitus: a nationwide population-based cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Jimin Jeon | - |
dc.contributor.googleauthor | Jinkwon Kim | - |
dc.identifier.doi | 10.1186/s12967-021-02934-y | - |
dc.contributor.localId | A01012 | - |
dc.relation.journalcode | J01915 | - |
dc.identifier.eissn | 1479-5876 | - |
dc.identifier.pmid | 34174896 | - |
dc.subject.keyword | Chronic Kidney Disease | - |
dc.subject.keyword | Cohort | - |
dc.subject.keyword | Dipstick proteinuria | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Kim, Jin Kwon | - |
dc.contributor.affiliatedAuthor | 김진권 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 271 | - |
dc.identifier.bibliographicCitation | JOURNAL OF TRANSLATIONAL MEDICINE, Vol.19(1) : 271, 2021-06 | - |
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