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Evaluation of anti-influenza effects of camostat in mice infected with non-adapted human influenza viruses
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 이민구 | - |
dc.date.accessioned | 2021-09-28T08:38:37Z | - |
dc.date.available | 2021-09-28T08:38:37Z | - |
dc.date.issued | 1996-06 | - |
dc.identifier.issn | 0304-8608 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183756 | - |
dc.description.abstract | The anti-influenza effects of camostat, a serine protease inhibitor, on in vivo influenza infections were evaluated. Mice which received non-adapted human influenza viruses intranasally, developed a reproducible infection with very low mortality. The infection was readily detected by the recovery of the virus from an oropharyngeal swab. Five-week-old ICR mice received intraperitoneal injections of saline (control), amantadine (known positive drug), or camostat, after infection with influenza A/Taiwan/1/86 virus. Virus detection was performed on day 1, 2, 3, 5, and 7 of postinfection. Both camostat and amantadine were effective in ameliorating mouse influenza. On day 5, mice injected with camostat (45%) or amantadine (50%) showed a lower virus secreting rate than those receiving saline (90%). Additionally, camostat showed strong anti-influenza effects on an amantadine-resistant type A virus and a type B virus infection in vitro. The results show that blocking the hemagglutinin cleavage is an effective target for development of an anti-influenza agent. They also demonstrate that virus detection from the oropharynx of mice, infected with non-adapted virus, is a useful in vivo influenza model. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | ARCHIVES OF VIROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adaptation, Physiological | - |
dc.subject.MESH | Amantadine / pharmacology | - |
dc.subject.MESH | Amantadine / therapeutic use* | - |
dc.subject.MESH | Amantadine / toxicity | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antiviral Agents / pharmacology | - |
dc.subject.MESH | Antiviral Agents / therapeutic use* | - |
dc.subject.MESH | Antiviral Agents / toxicity | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Drug Evaluation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gabexate* / analogs & derivatives* | - |
dc.subject.MESH | Guanidines / pharmacology | - |
dc.subject.MESH | Guanidines / therapeutic use* | - |
dc.subject.MESH | Guanidines / toxicity | - |
dc.subject.MESH | Influenza A virus / drug effects* | - |
dc.subject.MESH | Influenza B virus / drug effects* | - |
dc.subject.MESH | Lung / pathology | - |
dc.subject.MESH | Lung / virology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Nasal Lavage Fluid / virology | - |
dc.subject.MESH | Oropharynx / pathology | - |
dc.subject.MESH | Oropharynx / virology | - |
dc.subject.MESH | Orthomyxoviridae Infections / drug therapy* | - |
dc.subject.MESH | Orthomyxoviridae Infections / virology | - |
dc.title | Evaluation of anti-influenza effects of camostat in mice infected with non-adapted human influenza viruses | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | M G Lee | - |
dc.contributor.googleauthor | K H Kim | - |
dc.contributor.googleauthor | K Y Park | - |
dc.contributor.googleauthor | J S Kim | - |
dc.identifier.doi | 10.1007/BF01718208 | - |
dc.contributor.localId | A00311 | - |
dc.contributor.localId | A02781 | - |
dc.relation.journalcode | J00236 | - |
dc.identifier.eissn | 1432-8798 | - |
dc.identifier.pmid | 8920829 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/BF01718208 | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.contributor.affiliatedAuthor | 이민구 | - |
dc.citation.volume | 141 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1979 | - |
dc.citation.endPage | 1989 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF VIROLOGY, Vol.141(10) : 1979-1989, 1996-06 | - |
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