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The cholecystokinin receptor antagonist L-364,718 reduces taurocholate-induced pancreatitis in rats
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 김동구 | - |
dc.contributor.author | 이민구 | - |
dc.date.accessioned | 2021-09-28T08:02:19Z | - |
dc.date.available | 2021-09-28T08:02:19Z | - |
dc.date.issued | 1996-12 | - |
dc.identifier.issn | 0169-4197 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183368 | - |
dc.description.abstract | CONCLUSION: Our results suggest that the cholecystokinin (CCK) receptor antagonist L-364,718 has a protective effect on taurocholate-induced pancreatitis, and thus, it is inferred that CCK may have a significant pathophysiological role in the early phase of pancreatitis. BACKGROUND: Conflicting results have been obtained from studies designed to determine the role of CCK in the initial stages of pancreatitis. METHODS: We evaluated the protective effect of the CCK receptor antagonist L-364,718 (devazepide) and of the trypsin inhibitor camostat, on taurocholate-induced pancreatitis in rats. L-364,718 (1 mg/kg) or camostat (200 mg/kg) was administered intragastrically 30 min before the induction of pancreatitis. RESULTS: Infusion of sodium taurocholate (50 mg/kg) into the pancreaticobiliary duct caused severe pancreatitis with marked hyperamylasemia and reduction of tissue enzyme content at 12 h postinfusion. Pretreatment with L-364,718, but not with camostat, caused significant improvement in signs of experimental pancreatitis based on tissue enzyme content and morphology. Compared with untreated pancreatitis, there was relatively well-preserved lobular architecture, less edema, less infiltration of inflammatory cells, and more zymogen granules after L-364,718 pretreatment. Moreover, the reduction of enzyme content owing to pancreatitis was ameliorated by L-364,718 pretreatment. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Humana Press | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PANCREATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Amylases / blood | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Benzodiazepinones / pharmacology* | - |
dc.subject.MESH | Cholagogues and Choleretics / pharmacology | - |
dc.subject.MESH | Devazepide | - |
dc.subject.MESH | Gabexate* / analogs & derivatives* | - |
dc.subject.MESH | Guanidines / pharmacology | - |
dc.subject.MESH | Histocytochemistry | - |
dc.subject.MESH | Hormone Antagonists / pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Pancreas / drug effects | - |
dc.subject.MESH | Pancreas / pathology | - |
dc.subject.MESH | Pancreatitis / blood | - |
dc.subject.MESH | Pancreatitis / chemically induced | - |
dc.subject.MESH | Pancreatitis / pathology | - |
dc.subject.MESH | Pancreatitis / prevention & control* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, Cholecystokinin / antagonists & inhibitors | - |
dc.subject.MESH | Sincalide / antagonists & inhibitors | - |
dc.subject.MESH | Taurocholic Acid | - |
dc.subject.MESH | Trypsin Inhibitors / pharmacology | - |
dc.title | The cholecystokinin receptor antagonist L-364,718 reduces taurocholate-induced pancreatitis in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.contributor.googleauthor | Min Goo Lee | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.identifier.doi | 10.1007/BF02803770 | - |
dc.contributor.localId | A00311 | - |
dc.contributor.localId | A00396 | - |
dc.contributor.localId | A02781 | - |
dc.relation.journalcode | J04040 | - |
dc.identifier.eissn | 2363-5134 | - |
dc.identifier.pmid | 9013282 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2FBF02803770 | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.contributor.affiliatedAuthor | 김동구 | - |
dc.contributor.affiliatedAuthor | 이민구 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 205 | - |
dc.citation.endPage | 211 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PANCREATOLOGY, Vol.20(3) : 205-211, 1996-12 | - |
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