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Gamma/delta T lymphocytes in the BCG granulomatous lesions
DC Field | Value | Language |
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dc.contributor.author | 김동수 | - |
dc.contributor.author | 한석주 | - |
dc.date.accessioned | 2021-09-28T07:49:51Z | - |
dc.date.available | 2021-09-28T07:49:51Z | - |
dc.date.issued | 1996-10 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183211 | - |
dc.description.abstract | Recent studies in man and animal models have demonstrated that TCR-γδ-bearing T cells (γδ T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. Although the function of γδ T cells remains unclear, some data suggest a potential role for these cells in the granulomatous immune response. To address the presence of γδ T cells within the BCG granulomas, we have characterized the TCR phenotype of T-lymphocytes present in the BCG granulomatous lesion immunohistochemically using a monoclonal antibody to TCR δ1 and others. Fairly large numbers of γδ T cells were located at the periphery of the BCG granulomas without necrosis and most of them also expressed CD8. However, γδ T cells were rarely present in the granulomas with central caseous necrosis, calcification and fibrotic changes. With these results, it might be speculated that the CD8+ γδ T lymphocytes participate in the BCG granuloma formation mainly in the early stage. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Granuloma / immunology | - |
dc.subject.MESH | Granuloma / pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Lymph Nodes / pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mycobacterium bovis* | - |
dc.subject.MESH | Receptors, Antigen, T-Cell, gamma-delta / analysis* | - |
dc.subject.MESH | T-Lymphocytes / immunology* | - |
dc.subject.MESH | Tuberculosis / immunology | - |
dc.subject.MESH | Tuberculosis / pathology* | - |
dc.title | Gamma/delta T lymphocytes in the BCG granulomatous lesions | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Dong Soo Kim | - |
dc.contributor.googleauthor | Ki Young Lee | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Seok Joo Han | - |
dc.contributor.googleauthor | Eui Ho Hwang | - |
dc.identifier.doi | 10.3349/ymj.1996.37.5.319 | - |
dc.contributor.localId | A00405 | - |
dc.contributor.localId | A04288 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 8997164 | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.affiliatedAuthor | 김동수 | - |
dc.contributor.affiliatedAuthor | 한석주 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 319 | - |
dc.citation.endPage | 324 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.37(5) : 319-324, 1996-10 | - |
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