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The effect of statins on mortality among patients with infection: umbrella review of meta-analyses
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.contributor.author | 이금화 | - |
dc.date.accessioned | 2021-05-26T17:03:30Z | - |
dc.date.available | 2021-05-26T17:03:30Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1128-3602 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182971 | - |
dc.description.abstract | Objective: Although previous research has reported beneficial effects of statins on infectious diseases, these have yet to be concluded. Therefore, we conducted an umbrella review to provide a comprehensive understanding of the strength of evidence and validity of claimed associations between statins (hydroxymethyl glutaryl-CoA reductase inhibitors) and infectious diseases. Patients and methods: We conducted an umbrella review and re-analyzed data from meta-analyses of randomized controlled trials and observational studies on associations between statin use and different infectious diseases such as bacteremia/sepsis and pneumonia. We also evaluated the level of evidence for each re-analyzed outcome based on the criteria using p-values of random and fixed-effects, 95% prediction intervals, small-study effects, between-study heterogeneity, and concordance between the effect estimate of the largest study and summary estimates of the meta-analysis. Moreover, publication bias was also examined. Results: Through a systematic literature search, we obtained 14 eligible articles including 25 meta-analyses. All 4 meta-analyses on overall infection, 3 out of 14 meta-analyses on bacteremia/sepsis, and 5 out of 7 meta-analyses on pneumonia demonstrated that statin use was associated with reduced mortality due to infections (caused by infections). Nonetheless, most significant results only showed a weak level of evidence, and one study with convincing evidence prior to adjustment also showed weak evidence after adjustment. Conclusions: The present review identified a protective effect of statins on infection-related mortality, but all available studies had a weak level of evidence. Therefore, further studies with a strong level of evidence are needed, and it is also necessary to investigate the types of statins and to study clinical outcomes other than mortality to gain further insights. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Verduci | - |
dc.relation.isPartOf | EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The effect of statins on mortality among patients with infection: umbrella review of meta-analyses | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | ;Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | R A Ghayda | - |
dc.contributor.googleauthor | C H Han | - |
dc.contributor.googleauthor | K H Lee | - |
dc.contributor.googleauthor | J S Kim | - |
dc.contributor.googleauthor | S E Kim | - |
dc.contributor.googleauthor | S H Hong | - |
dc.contributor.googleauthor | M Kim | - |
dc.contributor.googleauthor | A Kronbichler | - |
dc.contributor.googleauthor | K Tizaoui | - |
dc.contributor.googleauthor | H Li | - |
dc.contributor.googleauthor | A Koyanagi | - |
dc.contributor.googleauthor | L Jacob | - |
dc.contributor.googleauthor | M S Kim | - |
dc.contributor.googleauthor | D K Yon | - |
dc.contributor.googleauthor | S W Lee | - |
dc.contributor.googleauthor | K Kostev | - |
dc.contributor.googleauthor | J I Shin | - |
dc.contributor.googleauthor | J W Yang | - |
dc.contributor.googleauthor | L Smith | - |
dc.identifier.doi | 10.26355/eurrev_202103_25432 | - |
dc.contributor.localId | A02142 | - |
dc.contributor.localId | A04622 | - |
dc.relation.journalcode | J03872 | - |
dc.identifier.eissn | 2284-0729 | - |
dc.identifier.pmid | 33829455 | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.contributor.affiliatedAuthor | 이금화 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2685 | - |
dc.citation.endPage | 2695 | - |
dc.identifier.bibliographicCitation | EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, Vol.25(6) : 2685-2695, 2021-04 | - |
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