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Benzodiazepine-Related Cognitive Impairment or Dementia: A Signal Detection Study Using a Case/Non-Case Approach
DC Field | Value | Language |
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dc.contributor.author | 김우정 | - |
dc.date.accessioned | 2021-05-21T17:09:35Z | - |
dc.date.available | 2021-05-21T17:09:35Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182735 | - |
dc.description.abstract | Objective: The association between benzodiazepine use and the risk of cognitive impairment or dementia has been controversial. Our study aims to detect this association through a case/non-case method using the Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database (KIDS-KD) between 2007 and 2016. Methods: Cases were adverse event (AE)-pairs with suspected cognitive impairment or dementia. 10 non-cases were matched to each case on age and sex. Exposure was defined as use of benzodiazepines, including long-, intermediate-, and short-acting benzodiazepine. We conducted multivariable logistic regression analyses to estimate reporting odds ratios (ROR) and 95% confidence intervals (CI). Results: Of the 1,086,584 AE-pairs, 887 cases were suspected AE-pairs of cognitive impairment or dementia, and 775,444 non-cases were selected. Benzodiazepine use was associated with increased AE-pairs of cognitive impairment or dementia when assessed using those with certain, probable, and/or possible in causality assessments (ROR=2.69, 95% CI=1.66-4.38). Higher ROR estimates were shown in female (2.33, 1.48-3.67) and in those with polypharmacy (2.20, 1.35-3.57). Dementia safety profiles were inconsistent across individual benzodiazepine components. Conclusion: These results suggest the potentially increased association between benzodiazepine use and cognitive impairment or dementia in female and those with polypharmacy. Inconsistent safety profiles of benzodiazepine components should be further investigated. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Neuropsychiatric Association | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Benzodiazepine-Related Cognitive Impairment or Dementia: A Signal Detection Study Using a Case/Non-Case Approach | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | Yeon-Hee Baek | - |
dc.contributor.googleauthor | Hye-Jun Kim | - |
dc.contributor.googleauthor | Ji-Hwan Bae | - |
dc.contributor.googleauthor | Hyesung Lee | - |
dc.contributor.googleauthor | In-Sun Oh | - |
dc.contributor.googleauthor | Woo Jung Kim | - |
dc.contributor.googleauthor | Ju-Young Shin | - |
dc.identifier.doi | 10.30773/pi.2019.0275 | - |
dc.contributor.localId | A04906 | - |
dc.relation.journalcode | J02569 | - |
dc.identifier.eissn | 1976-3026 | - |
dc.identifier.pmid | 32450620 | - |
dc.subject.keyword | Benzodiazepine | - |
dc.subject.keyword | Case/non-case | - |
dc.subject.keyword | Dementia | - |
dc.subject.keyword | Korea Institute of Drug Safety & Risk Management Korea Adverse Event Reporting System database (KIDS-KD) | - |
dc.subject.keyword | Signal detection | - |
dc.contributor.alternativeName | Kim, Woo Jung | - |
dc.contributor.affiliatedAuthor | 김우정 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 587 | - |
dc.citation.endPage | 595 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, Vol.17(6) : 587-595, 2020-06 | - |
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