Cited 9 times in
Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria
DC Field | Value | Language |
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dc.contributor.author | 김명진 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 서니은 | - |
dc.contributor.author | 정용은 | - |
dc.contributor.author | 최진영 | - |
dc.date.accessioned | 2020-12-11T08:01:06Z | - |
dc.date.available | 2020-12-11T08:01:06Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180743 | - |
dc.description.abstract | The Liver Imaging Reporting and Data System (LI-RADS) is widely adopted for the noninvasive diagnosis of hepatocellular carcinoma (HCC). Herein, possible strategies to improve the diagnostic performance of LR-5 without reducing specificity for HCC were investigated. This retrospective study included 792 patients who underwent gadoxetate disodium-enhanced magnetic resonance imaging. Hepatic observations were categorized according to LI-RADS v2018 and categories were readjusted by upgrading LR4 to LR5 using ancillary features, arterial phase hyperenhancement (APHE) interpreted with subtraction images, indication of no washout when APHE was absent, extension of washout to the transitional phase, and subthreshold growth as a major feature. Based on LI-RADS v2018, LR-5 showed a sensitivity of 71.9% and a specificity of 97.9% for the diagnosis of HCC. Category-readjusted LR-5 after upgrading LR-4 to LR-5 using ancillary features favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted using subtraction images showed significantly increased sensitivity (P<0.001) without decreased specificity (Ps>0.05). The sensitivity of LR-5 can be improved without loss of specificity via category readjustment using AFs favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted with subtraction images. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Jae Hyon Park | - |
dc.contributor.googleauthor | Yong Eun Chung | - |
dc.contributor.googleauthor | Nieun Seo | - |
dc.contributor.googleauthor | Jin-Young Choi | - |
dc.contributor.googleauthor | Mi-Suk Park | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.identifier.doi | 10.1371/journal.pone.0242344 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A01874 | - |
dc.contributor.localId | A03662 | - |
dc.contributor.localId | A04200 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 33186378 | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | 김명진 | - |
dc.contributor.affiliatedAuthor | 박미숙 | - |
dc.contributor.affiliatedAuthor | 서니은 | - |
dc.contributor.affiliatedAuthor | 정용은 | - |
dc.contributor.affiliatedAuthor | 최진영 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | e0242344 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.15(11) : e0242344, 2020-11 | - |
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