Cited 16 times in
Association of smoking with incident CKD risk in the general population: A community-based cohort study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 남기헌 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 윤해룡 | - |
dc.contributor.author | 이상미 | - |
dc.contributor.author | 조원지 | - |
dc.contributor.author | 주영수 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2020-12-01T17:02:49Z | - |
dc.date.available | 2020-12-01T17:02:49Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180099 | - |
dc.description.abstract | Background: Chronic kidney disease (CKD) is a public health problem, and an unfavorable lifestyle has been suggested as a modifiable risk factor for CKD. Cigarette smoking is closely associated with cardiovascular disease and cancers; however, there is a lack of evidence to prove that smoking is harmful for kidney health. Therefore, we aimed to determine the relationship between cigarette smoking and CKD among healthy middle-aged adults. Methods: Using the database from the Korean Genome and Epidemiology Study, we analyzed 8,661 participants after excluding those with baseline estimated glomerular filtration rate (eGFR)<60 ml/min/1.72 m2 or proteinuria. Exposure of interest was smoking status: never-, former-, and current-smokers. Primary outcome was incident CKD defined as eGFR <60 ml/min/1.73 m2 or newly developed proteinuria. Results: The mean age of the subjects was 52 years, and 47.6% of them were males. There were 551 (6.4%) and 1,255 (14.5%) subjects with diabetes and hypertension, respectively. The mean eGFR was 93.0 ml/min/1.73 m2. Among the participants, 5,140 (59.3%), 1,336 (15.4%), and 2,185 (25.2%) were never-smokers, former-smokers, and current-smokers, respectively. During a median follow-up of 11.6 years, incident CKD developed in 1,941 (22.4%) subjects with a crude incidence rate of 25.1 (24.0-26.2) per 1,000 person-years. The multivariable Cox regression analysis after adjustment of confounding factors showed hazard ratios (95% confidence interval) of 1.13 (0.95-1.35) and 1.26 (1.07-1.48) for CKD development in the former- and current-smokers, compared with never-smokers. Conclusion: This study showed that smoking was associated with a higher risk of incident CKD among healthy middle-aged adults. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate / physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Renal Insufficiency, Chronic / etiology* | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Tobacco Smoking / adverse effects* | - |
dc.title | Association of smoking with incident CKD risk in the general population: A community-based cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Wonji Jo | - |
dc.contributor.googleauthor | Sangmi Lee | - |
dc.contributor.googleauthor | Young Su Joo | - |
dc.contributor.googleauthor | Ki Heon Nam | - |
dc.contributor.googleauthor | Hae-Ryong Yun | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.contributor.googleauthor | Ea Wha Kang | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.identifier.doi | 10.1371/journal.pone.0238111 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01244 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04617 | - |
dc.contributor.localId | A05655 | - |
dc.contributor.localId | A05982 | - |
dc.contributor.localId | A03956 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 32853266 | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 남기헌 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 윤해룡 | - |
dc.contributor.affiliatedAuthor | 이상미 | - |
dc.contributor.affiliatedAuthor | 조원지 | - |
dc.contributor.affiliatedAuthor | 주영수 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | e0238111 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.15(8) : e0238111, 2020-08 | - |
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