Cited 11 times in
Impact of prognostic nutritional index on outcomes in patients with Mycobacterium avium complex pulmonary disease
DC Field | Value | Language |
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dc.contributor.author | 박무석 | - |
dc.contributor.author | 문성우 | - |
dc.contributor.author | 이수환 | - |
dc.contributor.author | 이상훈 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 김송이 | - |
dc.contributor.author | 강영애 | - |
dc.contributor.author | 정경수 | - |
dc.contributor.author | 정지예 | - |
dc.contributor.author | 이은혜 | - |
dc.contributor.author | 최지수 | - |
dc.contributor.author | 임아영 | - |
dc.date.accessioned | 2020-09-28T11:13:05Z | - |
dc.date.available | 2020-09-28T11:13:05Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179194 | - |
dc.description.abstract | Onodera's prognostic nutritional index (PNI) is useful in predicting prognosis of various diseases. But the usefulness of PNI in non-surgical patients has not been sufficiently proven yet. In patients with mycobacterium avium complex pulmonary disease (MAC-PD), malnutrition is an important factor that affects the quality of life and morbidity. Here, we aimed to evaluate whether PNI is related with clinical outcomes in MAC-PD patients. We examined 663 patients diagnosed with MAC-PD between May 2005 and November 2017. PNI score was calculated at the time of diagnosis and treatment initiation, and patients were divided into malnutrition and non-malnutrition groups according to a cut-off PNI score of 45. As the recommended duration of treatment for MAC-PD is 12 months following sputum conversion, treatment duration less than 12 months was defined as treatment intolerance. Survivals were compared with the log-rank test. Multivariate logistic regression and multivariate Cox proportional hazards models were used to estimate the odds ratio (OR) and hazards ratio (HR) for treatment intolerance and mortality, respectively. Of the 306 patients that received treatment, 193 received treatment longer than 12 months. In the multivariable logistic regression model, malnutrition at the time of treatment initiation was related with treatment intolerance (OR: 2.559, 95% confidence interval [CI]: 1.414-4.634, P = 0.002). Patients in the malnutrition group at the time of diagnosis exhibited lower survival (P<0.001) and malnutrition at the time of diagnosis was a significant risk for all-cause mortality (HR: 2.755, 95% CI: 1.610-4.475, P<0.001). Malnutrition, as defined by PNI, is an independent predictor for treatment intolerance and all-cause mortality in patients with MAC-PD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Anti-Bacterial Agents / therapeutic use* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Lung Diseases / diagnosis | - |
dc.subject.MESH | Lung Diseases / drug therapy* | - |
dc.subject.MESH | Lung Diseases / microbiology* | - |
dc.subject.MESH | Lung Diseases / mortality | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Malnutrition / diagnosis* | - |
dc.subject.MESH | Malnutrition / mortality | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycobacterium avium Complex* | - |
dc.subject.MESH | Mycobacterium avium-intracellulare Infection / diagnosis | - |
dc.subject.MESH | Mycobacterium avium-intracellulare Infection / drug therapy* | - |
dc.subject.MESH | Mycobacterium avium-intracellulare Infection / microbiology | - |
dc.subject.MESH | Mycobacterium avium-intracellulare Infection / mortality | - |
dc.subject.MESH | Nutrition Assessment* | - |
dc.subject.MESH | Nutritional Status | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Quality of Life | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sputum / microbiology | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Impact of prognostic nutritional index on outcomes in patients with Mycobacterium avium complex pulmonary disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Woo Moon | - |
dc.contributor.googleauthor | Eun Hye Lee | - |
dc.contributor.googleauthor | Ji Soo Choi | - |
dc.contributor.googleauthor | Ah Young Leem | - |
dc.contributor.googleauthor | Su Hwan Lee | - |
dc.contributor.googleauthor | Sang Hoon Lee | - |
dc.contributor.googleauthor | Song Yee Kim | - |
dc.contributor.googleauthor | Kyung Soo Chung | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.identifier.doi | 10.1371/journal.pone.0232714 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A01363 | - |
dc.contributor.localId | A02904 | - |
dc.contributor.localId | A02836 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A00626 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A03570 | - |
dc.contributor.localId | A03735 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 32374770 | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | 박무석 | - |
dc.contributor.affiliatedAuthor | 문성우 | - |
dc.contributor.affiliatedAuthor | 이수환 | - |
dc.contributor.affiliatedAuthor | 이상훈 | - |
dc.contributor.affiliatedAuthor | 김영삼 | - |
dc.contributor.affiliatedAuthor | 김송이 | - |
dc.contributor.affiliatedAuthor | 강영애 | - |
dc.contributor.affiliatedAuthor | 정경수 | - |
dc.contributor.affiliatedAuthor | 정지예 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e0232714 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.15(5) : e0232714, 2020-05 | - |
dc.identifier.rimsid | 67372 | - |
dc.type.rims | ART | - |
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