Cited 64 times in
Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease
DC Field | Value | Language |
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dc.contributor.author | 류철형 | - |
dc.contributor.author | 조한나 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 최재용 | - |
dc.date.accessioned | 2020-09-28T00:56:55Z | - |
dc.date.available | 2020-09-28T00:56:55Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1552-5260 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178996 | - |
dc.description.abstract | Introduction: Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) "typical", (2) "limbic-predominant", (3) "hippocampal-sparing", and (4) "mild atrophy". We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Methods: The four subtypes were replicated using a clustering method on MRI data in 260 amyloid-β-positive patients with mild cognitive impairment or AD dementia, and we subsequently tested whether the subtypes differed on [18 F]flortaucipir (tau) positron emission tomography, white matter hyperintensity burden, and rate of global cognitive decline. Results: Voxel-wise and region-of-interest analyses revealed the greatest neocortical tau load in hippocampal-sparing (frontoparietal-predominant) and typical (temporal-predominant) patients, while limbic-predominant patients showed particularly high entorhinal tau. Typical patients with AD had the most pronounced white matter hyperintensity load, and hippocampal-sparing patients showed the most rapid global cognitive decline. Discussion: Our data suggest that structural MRI can be used to identify biologically and clinically meaningful subtypes of AD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | ALZHEIMERS & DEMENTIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Rik Ossenkoppele | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.contributor.googleauthor | Carole H Sudre | - |
dc.contributor.googleauthor | Danielle van Westen | - |
dc.contributor.googleauthor | Hanna Cho | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Jae Yong Choi | - |
dc.contributor.googleauthor | Ruben Smith | - |
dc.contributor.googleauthor | Olof Strandberg | - |
dc.contributor.googleauthor | Sebastian Palmqvist | - |
dc.contributor.googleauthor | Eric Westman | - |
dc.contributor.googleauthor | Richard Tsai | - |
dc.contributor.googleauthor | Joel Kramer | - |
dc.contributor.googleauthor | Adam L Boxer | - |
dc.contributor.googleauthor | Maria L Gorno-Tempini | - |
dc.contributor.googleauthor | Renaud La Joie | - |
dc.contributor.googleauthor | Bruce L Miller | - |
dc.contributor.googleauthor | Gil D Rabinovici | - |
dc.contributor.googleauthor | Oskar Hansson | - |
dc.identifier.doi | 10.1016/j.jalz.2019.08.201 | - |
dc.contributor.localId | A01333 | - |
dc.contributor.localId | A03920 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A04695 | - |
dc.relation.journalcode | J00068 | - |
dc.identifier.eissn | 1552-5279 | - |
dc.identifier.pmid | 31672482 | - |
dc.subject.keyword | Alzheimer's disease | - |
dc.subject.keyword | Atrophy | - |
dc.subject.keyword | Cognition | - |
dc.subject.keyword | Dementia | - |
dc.subject.keyword | Subtypes | - |
dc.subject.keyword | Tau | - |
dc.subject.keyword | Thickness | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | 류철형 | - |
dc.contributor.affiliatedAuthor | 조한나 | - |
dc.contributor.affiliatedAuthor | 유영훈 | - |
dc.contributor.affiliatedAuthor | 최재용 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 335 | - |
dc.citation.endPage | 344 | - |
dc.identifier.bibliographicCitation | ALZHEIMERS & DEMENTIA, Vol.16(2) : 335-344, 2020-02 | - |
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