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테트라싸이크린 함유 calcium sulfate의 서방형 국소 약물 송달 효과에 대한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종관 | - |
dc.contributor.author | 박광균 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 채중규 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2020-07-03T17:53:27Z | - |
dc.date.available | 2020-07-03T17:53:27Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0250-3352 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177914 | - |
dc.description.abstract | Periodontal disease is a bacterially caused by disease. To remove plaque and bacteria, it has been necessary to prescribe chemical drug to patient to subjugate therapeutic unvalue by mechanical scaling. As a patient on a high dosage of the antibiotics to maintain the effective concentration may produce unfavorable side effects, this decase demands the Slow-release local drug delivery system. The object of the experiment is to study on the slow-release local drug delivery effects of calcium sulfate compounded with tetracycline that mainly used in periodontal disease. Experimental groups were divided into four classes as follow: Group 1 : 10% tetracycline compounded modified calcium sulfate paste. Group 2 : compounded and hardened 10% tetracycline and calcium sulfate. Group 3 : compounded 10% tetracycline and calcium sulfate, used just before hardened. Group 4 : tetracycline-ethylene vinyl acetate fiber. In the four groups, release concentration, it's durability and the period of absorption by times are observed and concluded as follow: An effective concentration(4µm/ml) remained until 5 weeks in group 1, 9 days in group 2, 7 days in group 3, 15 days in group 4. It was fully fused at 11.8 days average in group 2 and 14.8 days average in group 3. There were no statistically significant results in tetracycline concentration until a week in group 2 and 3(p<0.05) These results suggest that tetracycline loaded calcium sulfate release sufficient tetracycline and fused in 11~14 days, so calcium sulfate is useful carrier as slow release local drug delivery system | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한치주과학회 | - |
dc.relation.isPartOf | Journal of Korean Academy of Periodontology (대한치주과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 테트라싸이크린 함유 calcium sulfate의 서방형 국소 약물 송달 효과에 대한 연구 | - |
dc.title.alternative | Slow-release local drug delivery effect of tetracycline loaded calcium sulfate | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontics (치주과학교실) | - |
dc.contributor.googleauthor | 김성희 | - |
dc.contributor.googleauthor | 최성호 | - |
dc.contributor.googleauthor | 조규성 | - |
dc.contributor.googleauthor | 채중규 | - |
dc.contributor.googleauthor | 박광균 | - |
dc.contributor.googleauthor | 김종관 | - |
dc.contributor.localId | A00914 | - |
dc.contributor.localId | A01429 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A04024 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J01492 | - |
dc.contributor.alternativeName | Kim, Chong Kwan | - |
dc.contributor.affiliatedAuthor | 김종관 | - |
dc.contributor.affiliatedAuthor | 박광균 | - |
dc.contributor.affiliatedAuthor | 조규성 | - |
dc.contributor.affiliatedAuthor | 채중규 | - |
dc.contributor.affiliatedAuthor | 최성호 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 751 | - |
dc.citation.endPage | 765 | - |
dc.identifier.bibliographicCitation | Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.27(4) : 751-765, 1997 | - |
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