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Differences in Flow-Gradient Patterns Between Severe Bicuspid Aortic Stenosis and Severe Tricuspid Aortic Stenosis - Mechanistic Insight From Multimodal Imaging
DC Field | Value | Language |
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dc.contributor.author | 김영진 | - |
dc.contributor.author | 심지영 | - |
dc.contributor.author | 이삭 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 하종원 | - |
dc.contributor.author | 홍그루 | - |
dc.contributor.author | 남경선 | - |
dc.date.accessioned | 2020-02-26T06:32:59Z | - |
dc.date.available | 2020-02-26T06:32:59Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1346-9843 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175195 | - |
dc.description.abstract | BACKGROUND: We investigated the flow-gradient pattern characteristics and associated factors in severe bicuspid aortic stenosis (AS) compared with severe tricuspid AS.Methods and Results:A total of 252 patients with severe AS (115 bicuspid vs. 137 tricuspid) who underwent aortic valve (AV) replacement were retrospectively analyzed. Patients were classified into 4 groups according to stroke volume index and mean pressure gradient across the AV [normal-flow-high-gradient (NF-HG), low-flow-high-gradient, normal-flow-low-gradient, low-flow-low-gradient (LF-LG)]. In 89 patients who underwent cardiac computed tomography (CT), influential structural parameters of the left ventricular outflow tract (LVOT), AV and ascending aorta were assessed. Bicuspid AS was more likely to present a NF-HG pattern (83.5% vs. 64.2%, P<0.001), and significantly fewer presented a LF-LG pattern compared with tricuspid AS. In bicuspid AS, there was a significant mismatch between geometric orifice area (GOA) on CT planimetry and effective orifice area (EOA) calculated using the echocardiographic continuity equation. Bicuspid AS presented with a larger angle between the LVOT-AV and aorta. Multivariate analysis of bicuspid AS revealed that systemic arterial compliance (β=-0.350, P=0.031) and the LVOT-AV-aorta angle (β=-0.538, P=0.001), and stroke volume index (β=0.409, P=0.008) were associated with a discrepancy between GOA and EOA. CONCLUSIONS: Flow-gradient patterns in bicuspid AS differ from those of tricuspid AS and are associated with the structural and functional characteristics of the aorta. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Japanese | - |
dc.publisher | Japanese Circulation Society | - |
dc.relation.isPartOf | CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Differences in Flow-Gradient Patterns Between Severe Bicuspid Aortic Stenosis and Severe Tricuspid Aortic Stenosis - Mechanistic Insight From Multimodal Imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Darae Kim | - |
dc.contributor.googleauthor | Chi Young Shim | - |
dc.contributor.googleauthor | Young Jin Kim | - |
dc.contributor.googleauthor | Kyungsun Nam | - |
dc.contributor.googleauthor | Geu-Ru Hong | - |
dc.contributor.googleauthor | Seung Hyun Lee | - |
dc.contributor.googleauthor | Sak Lee | - |
dc.contributor.googleauthor | Jong-Won Ha | - |
dc.identifier.doi | 10.1253/circj.CJ-19-0702 | - |
dc.contributor.localId | A00727 | - |
dc.contributor.localId | A02213 | - |
dc.contributor.localId | A02807 | - |
dc.contributor.localId | A02935 | - |
dc.contributor.localId | A04257 | - |
dc.contributor.localId | A04386 | - |
dc.relation.journalcode | J00534 | - |
dc.identifier.eissn | 1347-4820 | - |
dc.identifier.pmid | 31787664 | - |
dc.subject.keyword | Bicuspid aortic stenosis | - |
dc.subject.keyword | Cardiac computed tomography | - |
dc.subject.keyword | Echocardiography | - |
dc.contributor.alternativeName | Kim, Young Jin | - |
dc.contributor.affiliatedAuthor | 김영진 | - |
dc.contributor.affiliatedAuthor | 심지영 | - |
dc.contributor.affiliatedAuthor | 이삭 | - |
dc.contributor.affiliatedAuthor | 이승현 | - |
dc.contributor.affiliatedAuthor | 하종원 | - |
dc.contributor.affiliatedAuthor | 홍그루 | - |
dc.citation.volume | 84 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 119 | - |
dc.citation.endPage | 126 | - |
dc.identifier.bibliographicCitation | CIRCULATION JOURNAL, Vol.84(1) : 119-126, 2020-01 | - |
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