Cited 4 times in
Outcomes of pathologically localized high-grade prostate cancer treated with radical prostatectomy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종찬 | - |
dc.contributor.author | 나군호 | - |
dc.contributor.author | 박지수 | - |
dc.contributor.author | 이종수 | - |
dc.contributor.author | 장원식 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 함원식 | - |
dc.contributor.author | 허지은 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2019-12-18T00:38:51Z | - |
dc.date.available | 2019-12-18T00:38:51Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173158 | - |
dc.description.abstract | Adjuvant radiation therapy (ART) is recommended without consideration of radical prostatectomy Gleason score (RP GS) for cases with adverse features. We compared the outcomes of pathologically localized high-grade (GS 8-10) prostate cancer (PC) with those of pT3 GS 7 PC.A total of 1585 men who underwent RP between 1995 and 2015 comprised the cohort, which was divided into group 1 (RP GS 7(3 + 4) and pT3; n = 760), group 2 (RP GS 7(4 + 3) and pT3; n = 565), and group 3 (RP GS 8-10 and pT2; n = 260). Biochemical recurrence (BCR), all-cause mortality (ACM), and PC-specific mortality (PCSM) risk were compared among groups using Cox regression and competing risk analysis.At a median follow-up of 58 months (interquartile range: 37-85), 721 men experienced BCR and 84 died (22 due to PC). BCR-free survival rates were lower in group 3 than in group 1 (P < .001); nevertheless, no difference was observed between groups 2 and 3 (P = .638). Furthermore, no difference in ACM was noted among groups. PCSM rates were higher in group 3 than in groups 1 and 2 (P = .001 and P = .005, respectively). This association persisted in multivariate models after adjustment for clinicopathological variables.Patients with RP GS 8-10 and pT2 PC had higher BCR and PCSM rates than those with RP GS 7 and pT3 PC. Localized high-grade PC should be considered in decision-making for ART. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cause of Death/trends | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading/methods* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prostate/pathology* | - |
dc.subject.MESH | Prostate/surgery | - |
dc.subject.MESH | Prostatectomy/methods* | - |
dc.subject.MESH | Prostatic Neoplasms/diagnosis* | - |
dc.subject.MESH | Prostatic Neoplasms/mortality | - |
dc.subject.MESH | Prostatic Neoplasms/surgery | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate/trends | - |
dc.title | Outcomes of pathologically localized high-grade prostate cancer treated with radical prostatectomy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Ji Eun Heo | - |
dc.contributor.googleauthor | Jee Soo Park | - |
dc.contributor.googleauthor | Jong Soo Lee | - |
dc.contributor.googleauthor | Jongchan Kim | - |
dc.contributor.googleauthor | Won Sik Jang | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Won Sik Ham | - |
dc.identifier.doi | 10.1097/MD.0000000000017627 | - |
dc.contributor.localId | A04541 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A05336 | - |
dc.contributor.localId | A05500 | - |
dc.contributor.localId | A05268 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04337 | - |
dc.contributor.localId | A05531 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 31626145 | - |
dc.contributor.alternativeName | Kim, Jong Chan | - |
dc.contributor.affiliatedAuthor | 김종찬 | - |
dc.contributor.affiliatedAuthor | 나군호 | - |
dc.contributor.affiliatedAuthor | 박지수 | - |
dc.contributor.affiliatedAuthor | 이종수 | - |
dc.contributor.affiliatedAuthor | 장원식 | - |
dc.contributor.affiliatedAuthor | 최영득 | - |
dc.contributor.affiliatedAuthor | 함원식 | - |
dc.contributor.affiliatedAuthor | 허지은 | - |
dc.contributor.affiliatedAuthor | 홍성준 | - |
dc.citation.volume | 98 | - |
dc.citation.number | 42 | - |
dc.citation.startPage | e17627 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.98(42) : e17627, 2019 | - |
dc.identifier.rimsid | 63733 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.