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Role of protein kinases on NF- kappaB activation and cell death in bovine cerebral endothelial cells
DC Field | Value | Language |
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dc.contributor.author | 김철훈 | - |
dc.contributor.author | 안영수 | - |
dc.date.accessioned | 2019-11-26T01:18:32Z | - |
dc.date.available | 2019-11-26T01:18:32Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172917 | - |
dc.description.abstract | Nuclear factor kappaB (NF- kappaB) activation is modulated by various protein kinases. Activation of NF- kappaB is known to be important in the regulation of cell viability. The present study investigated the effect of inhibitors of protein tyrosine kinase (PTK), protein kinase C (PKC) and protein kinase A (PKA) on NF- kappaB activity and the viability of bovine cerebral endothelial cells (BCECs). In serum-deprivation-induced BCEC death, low doses of TNF alpha showed a protective effect. TNF alpha induced NF- kappaB activation within 4 h in serum-deprivation. PTK inhibitors (herbimycin A and genistein) and PKC inhibitor (calphostin C) prevented NF- kappaB activation stimulated by TNF alpha. Likewise, these inhibitors prevented the protective effect of TNF alpha. In contrast to TNF alpha-stimulated NF- kappaB activity, basal NF- kappaB activity of BCECs in media containing serum was suppressed only by calphostin C, but not by herbimycin A. As well BCEC death was also induced only by calphostin C in serum-condition. H 89, a PKA inhibitor, did not affect the basal and TNF alpha-stimulated NF- kappaB activities and the protective effect of TNF alpha on cell death. These data suggest that modulation of NF- kappaB activation could be a possible mechanism for regulating cell viability by protein kinases in BCECs. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한약리학회 | - |
dc.relation.isPartOf | Korean Journal of Physiology & Pharmacology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Role of protein kinases on NF- kappaB activation and cell death in bovine cerebral endothelial cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Young Soo Ahn | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Joo Hee Kim | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A02246 | - |
dc.relation.journalcode | J02104 | - |
dc.identifier.eissn | 2093-3827 | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | Cerebral endothelial cell death | - |
dc.subject.keyword | Protein kinase | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | 김철훈 | - |
dc.contributor.affiliatedAuthor | 안영수 | - |
dc.citation.volume | 3 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 11 | - |
dc.citation.endPage | 18 | - |
dc.identifier.bibliographicCitation | Korean Journal of Physiology & Pharmacology, Vol.3(1) : 11-18, 1999 | - |
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