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Helicobacter pylori 감염증 치료에 실패한 환자의 임상상과 항생제 내성
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 이용찬 | - |
dc.date.accessioned | 2019-11-26T01:02:40Z | - |
dc.date.available | 2019-11-26T01:02:40Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172688 | - |
dc.description.abstract | Background/Aims: The decisive factors influencing the eradication of H. pylori still remain unclear To identify such factors, we investigated the clinical characteristics and antibiotic resistance of patients. Methods: Patients with H. pylori infection were treated with dual or triple regimens. Eradi cation rates were analyzed on the basis of clinical factors, endoscopic factors and antibiotic resistance Results: Sixty-three H. pylori infected patients were enrolled (mean age 49.4). The eradication rate was significantly higher in compliant patients (71.9%) than in non-compliant patients (20%). Other clinical and endoscopic factors did not significantly influence the outcome of treatment. In 42 isolated strains, metronidazole resistance (MIC>8 μg/mL) was observed in 35.7% of the strains and clari thromycin resistance (MIC>2 μg/mL) was observed in 7.1%. The eradication rate in metronidazole resistant strains was 55.5%, which was lower than that in metronidazole sensitive strains (78.6%) The median value of metronidazole MIC in the group of successful eradication (0.94 μg/mL) was significantly lower than that in the group of failed eradication (64.0 μg/mL). Conclusions: Patient' s compliance for regimens seems to be the most important factor which affect H. pylori eradication Metronidazole resistance which is highly prevalent in our population may influence the efficacy of anti-H. pylori treatment regimen containing metronidazole. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean Journal of Gastroenterology | - |
dc.publisher | Korean Journal of Gastroenterology | - |
dc.relation.isPartOf | Korean Journal of Gastroenterology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Helicobacter pylori 감염증 치료에 실패한 환자의 임상상과 항생제 내성 | - |
dc.title.alternative | Clinical Characteristics of Patients with Failed Eradication of Helicobacter pylori and Antibiotic Resistance | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 유효민 | - |
dc.contributor.googleauthor | 이용찬 | - |
dc.contributor.googleauthor | 박효진 | - |
dc.contributor.googleauthor | 김원호 | - |
dc.contributor.googleauthor | 이경원 | - |
dc.contributor.googleauthor | ·박인서 | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A02988 | - |
dc.relation.journalcode | J02015 | - |
dc.identifier.eissn | 2233-6869 | - |
dc.subject.keyword | Helicobacter pylori | - |
dc.subject.keyword | Failed eradication | - |
dc.subject.keyword | Antibiotic resistance | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | 김원호 | - |
dc.contributor.affiliatedAuthor | 이경원 | - |
dc.contributor.affiliatedAuthor | 이용찬 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 311 | - |
dc.citation.endPage | 320 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gastroenterology, Vol.33(3) : 311-320, 1999 | - |
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