Cited 11 times in
Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori
DC Field | Value | Language |
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dc.contributor.author | 차정헌 | - |
dc.contributor.author | 장성일 | - |
dc.date.accessioned | 2019-10-28T02:06:23Z | - |
dc.date.available | 2019-10-28T02:06:23Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171488 | - |
dc.description.abstract | Infection with CagA+ Helicobacter pylori strains is linked to an increased risk for gastric diseases, including gastric cancer. Recent evidence indicates that dynamic expansion and contraction of cagA copy number may serve as a novel mechanism to enhance disease development. Herein, comparative genomic analysis divided hpEurope into two groups: hpEurope/type-A and type-B. Only hpEurope/type-B displayed the multi-cagA genotype. Further analysis showed that cagPAI appears to have been independently introduced into two different H. pylori types, termed pre-type-A and pre-type-B, which consequently evolved to cagPAI type-A and type-B, respectively; importantly, all multi-cagA genotype strains displayed cagPAI type-B. Two direct cagA-flanking repeats of a genetic element termed CHA-ud were essential for the multi-cagA genotype in strain PMSS1 (hpEurope/type-B and cagPAI type-B). Furthermore, introduction of this genetic element into strain G27 (hpEurope/type-A and cagPAI type-A) was sufficient to generate the multi-cagA genotype. The critical steps in the evolution of the multi-cagA genotype involved creation of CHA-ud at cagA upstream in cagPAI type-B strains followed by its duplication to cagA downstream. En masse, elucidation of the mechanism by which H. pylori evolved to carry multiple copies of cagA helps to provide a better understanding of how this ancient pathogen interacts with its host. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Scientific Reports | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Hanfu Su | - |
dc.contributor.googleauthor | Kavinda Tissera | - |
dc.contributor.googleauthor | Sungil Jang | - |
dc.contributor.googleauthor | Yun Hui Choi | - |
dc.contributor.googleauthor | Aeryun Kim | - |
dc.contributor.googleauthor | Yong-Joon Cho | - |
dc.contributor.googleauthor | Meiling Li | - |
dc.contributor.googleauthor | Niluka Gunawardhana | - |
dc.contributor.googleauthor | D. Scott Merrell | - |
dc.contributor.googleauthor | Linhu Ge | - |
dc.contributor.googleauthor | Jeong-Heon Cha | - |
dc.identifier.doi | 10.1038/s41598-019-47240-2 | - |
dc.contributor.localId | A04007 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 31371778 | - |
dc.contributor.alternativeName | Cha, Jung Heon | - |
dc.contributor.affiliatedAuthor | 차정헌 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 11203 | - |
dc.identifier.bibliographicCitation | Scientific Reports, Vol.9(1) : 11203, 2019 | - |
dc.identifier.rimsid | 63984 | - |
dc.type.rims | ART | - |
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