Cited 17 times in
Higher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients
DC Field | Value | Language |
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dc.contributor.author | 강신애 | - |
dc.contributor.author | 김경래 | - |
dc.contributor.author | 김민경 | - |
dc.contributor.author | 박종숙 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 유지홍 | - |
dc.contributor.author | 이민영 | - |
dc.date.accessioned | 2019-10-28T01:53:04Z | - |
dc.date.available | 2019-10-28T01:53:04Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171385 | - |
dc.description.abstract | BACKGROUND/AIMS: The importance of α-cell dysfunction in the pathogenesis of type 2 diabetes has re-emerged recently. However, data on whether relative glucagon excess is present in clinical settings are scarce. We aimed to investigate associations between glucagon-to-insulin ratio and various metabolic parameters. METHODS: A total of 451 patients with type 2 diabetes naïve to insulin treatment were recruited. Using glucagon-to-insulin ratio, we divided subjects into quartiles according to both fasting and postprandial glucagon-to-insulin ratios. RESULTS: The mean age of the subjects was 58 years, with a mean body mass index of 25 kg/m2 . The patients in the highest quartile of glucagon-to-insulin ratio had higher glycated hemoglobin (HbA1c) levels. HbA1c levels were positively correlated with both fasting and postprandial glucagon-to-insulin ratios. Subjects in the highest quartile of postprandial glucagon-to-insulin ratio were more likely to exhibit uncontrolled hyperglycemia, even after adjusting for confounding factors (odds ratio, 2.730; 95% confidence interval, 1.236 to 6.028; p for trend < 0.01). CONCLUSION: Hyperglucagonemia relative to insulin could contribute to uncontrolled hyperglycemia in type 2 diabetes patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Association of Internal Medicine | - |
dc.relation.isPartOf | Korean Journal of Internal Medicine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Higher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Minyoung Lee | - |
dc.contributor.googleauthor | Minkyung Kim | - |
dc.contributor.googleauthor | Jong Suk Park | - |
dc.contributor.googleauthor | Sangbae Lee | - |
dc.contributor.googleauthor | Jihong You | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Kyung Rae Kim | - |
dc.contributor.googleauthor | Shinae Kang | - |
dc.identifier.doi | 10.3904/kjim.2016.233 | - |
dc.contributor.localId | A00052 | - |
dc.contributor.localId | A00294 | - |
dc.contributor.localId | A00457 | - |
dc.contributor.localId | A01660 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A04984 | - |
dc.contributor.localId | A05491 | - |
dc.relation.journalcode | J02883 | - |
dc.identifier.eissn | 2005-6648 | - |
dc.identifier.pmid | 28882024 | - |
dc.subject.keyword | Diabetes mellitus, type 2 | - |
dc.subject.keyword | Glucagon | - |
dc.subject.keyword | Hemoglobin A, glycosylated | - |
dc.subject.keyword | Hyperglycemia | - |
dc.subject.keyword | Insulin | - |
dc.contributor.alternativeName | Kang, Shin Ae | - |
dc.contributor.affiliatedAuthor | 강신애 | - |
dc.contributor.affiliatedAuthor | 김경래 | - |
dc.contributor.affiliatedAuthor | 김민경 | - |
dc.contributor.affiliatedAuthor | 박종숙 | - |
dc.contributor.affiliatedAuthor | 안철우 | - |
dc.contributor.affiliatedAuthor | 유지홍 | - |
dc.contributor.affiliatedAuthor | 이민영 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1068 | - |
dc.citation.endPage | 1077 | - |
dc.identifier.bibliographicCitation | Korean Journal of Internal Medicine, Vol.34(5) : 1068-1077, 2019 | - |
dc.identifier.rimsid | 63833 | - |
dc.type.rims | ART | - |
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