Cited 53 times in
Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy
DC Field | Value | Language |
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dc.contributor.author | 남기택 | - |
dc.date.accessioned | 2019-07-23T06:41:42Z | - |
dc.date.available | 2019-07-23T06:41:42Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170274 | - |
dc.description.abstract | A major challenge in cancer treatment is the development of effectivetumor-specifictherapeutic methods that have minimal side effects. Recently, a photodynamictherapy(PDT) technique using activatable photosensitizers (aPSs) has shown great potential for cancer-specific treatment. Here, we develop asequentialprotein-responsiveaPS (PcC4-MSN-O1) that is based on zinc(II) phthalocyanine derivative (PcC4)-entrapped mesoporous silica nanoparticles (MSNs) and a wrapping DNA (O1) as a biogate. Inside the nanostructure of PcC4-MSN-O1, PcC4 shows self-quenching photoactivity. However, when PcC4-MSN-O1 sequentially reacts with telomerase and albumin, its photoactivity is dramatically turned on. Therefore, PcC4-MSN-O1 displays selective phototoxicity against cancer cells ( e.g., HeLa) over normal cells ( e.g., HEK-293). Following systemic PcC4-MSN-O1 administration, there is an obvious accumulation in HeLa tumors of xenograft-bearing mice, and laser irradiation clearly induces the inhibition of tumor growth. Moreover, the time-modulated activation process in tumors and the relatively fast excretion of PcC4-MSN-O1 indicate its advantages in reducing potential side effects. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | ACS NANO | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Xingshu Li | - |
dc.contributor.googleauthor | Huanhuan Fan | - |
dc.contributor.googleauthor | Tian Guo | - |
dc.contributor.googleauthor | Huarong Bai | - |
dc.contributor.googleauthor | Nahyun Kwon | - |
dc.contributor.googleauthor | Kwang H. Kim | - |
dc.contributor.googleauthor | Sungsook Yu | - |
dc.contributor.googleauthor | Yejin Cho | - |
dc.contributor.googleauthor | Hyunji Kim | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.contributor.googleauthor | Juyoung Yoon | - |
dc.contributor.googleauthor | Xiao-Bing Zhang | - |
dc.contributor.googleauthor | Weihong Tan | - |
dc.identifier.doi | 10.1021/acsnano.9b01100 | - |
dc.contributor.localId | A01243 | - |
dc.relation.journalcode | J00005 | - |
dc.identifier.eissn | 1936-086X | - |
dc.identifier.pmid | 31184131 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsnano.9b01100 | - |
dc.subject.keyword | activatable | - |
dc.subject.keyword | nanophotosensitizer | - |
dc.subject.keyword | photodynamictherapy | - |
dc.subject.keyword | phthalocyanine | - |
dc.subject.keyword | protein-responsive | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.affiliatedAuthor | 남기택 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 6702 | - |
dc.citation.endPage | 6710 | - |
dc.identifier.bibliographicCitation | ACS NANO, Vol.13(6) : 6702-6710, 2019 | - |
dc.identifier.rimsid | 61867 | - |
dc.type.rims | ART | - |
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