Cited 27 times in
Implantable Vascularized Liver Chip for Cross‐Validation of Disease Treatment with Animal Model
DC Field | Value | Language |
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dc.contributor.author | 김대현 | - |
dc.contributor.author | 박정수 | - |
dc.contributor.author | 배수한 | - |
dc.contributor.author | 성학준 | - |
dc.contributor.author | 이다현 | - |
dc.date.accessioned | 2019-07-23T06:34:08Z | - |
dc.date.available | 2019-07-23T06:34:08Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170213 | - |
dc.description.abstract | Artificial liver models have been extensively developed for pathological modeling and toxicological studies. However, the prediction of existing in vitro liver models rarely corresponds to what is consequently observed in vivo owing to the structural and functional complexity of the liver. Here, a new liver model designed to enable the implantation and maintenance of liver buds in perfusable 3D hydrogels where a microvascular network develops within a 200 µm diffusion limit is developed. This system replicates inflammation, lipid accumulation, and fibrosis during the progressive processes of nonalcoholic fatty liver disease, in which this model predicted the results from a mouse model. This model reveals that a hepatic steatosis‐reducing drug restored mitochondrial activities with significant reduction of inflammation, oxidative stress, and lipid accumulation. This liver model is not only highly predictive but also scalable and easy to apply to high‐throughput drug screening and implantation studies, suggesting a promising alternative to animal models. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isPartOf | ADVANCED FUNCTIONAL MATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Implantable Vascularized Liver Chip for Cross‐Validation of Disease Treatment with Animal Model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Jung Bok Lee | - |
dc.contributor.googleauthor | Jeong Su Park | - |
dc.contributor.googleauthor | Young Min Shin | - |
dc.contributor.googleauthor | Da Hyun Lee | - |
dc.contributor.googleauthor | Jeong‐Kee Yoon | - |
dc.contributor.googleauthor | Dae‐Hyun Kim | - |
dc.contributor.googleauthor | Ung Hyun Ko | - |
dc.contributor.googleauthor | YongTae Kim | - |
dc.contributor.googleauthor | Soo Han Bae | - |
dc.contributor.googleauthor | Hak‐Joon Sung | - |
dc.identifier.doi | 10.1002/adfm.201900075 | - |
dc.contributor.localId | A04717 | - |
dc.contributor.localId | A01645 | - |
dc.contributor.localId | A01798 | - |
dc.contributor.localId | A01958 | - |
dc.relation.journalcode | J00041 | - |
dc.identifier.eissn | 1616-3028 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201900075 | - |
dc.subject.keyword | 3D vascular network | - |
dc.subject.keyword | animal model | - |
dc.subject.keyword | liver bud | - |
dc.subject.keyword | liver chip | - |
dc.subject.keyword | nonalcoholic fatty liver disease | - |
dc.contributor.alternativeName | Kim, Dae-Hyun | - |
dc.contributor.affiliatedAuthor | 김대현 | - |
dc.contributor.affiliatedAuthor | 박정수 | - |
dc.contributor.affiliatedAuthor | 배수한 | - |
dc.contributor.affiliatedAuthor | 성학준 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 1900075 | - |
dc.identifier.bibliographicCitation | ADVANCED FUNCTIONAL MATERIALS, Vol.29(23) : 1900075, 2019 | - |
dc.identifier.rimsid | 61873 | - |
dc.type.rims | ART | - |
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