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Expression of sarcosine-metabolizing enzymes in thyroid cancer
DC Field | Value | Language |
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dc.contributor.author | 김혜민 | - |
dc.contributor.author | 구자승 | - |
dc.contributor.author | 이유경 | - |
dc.date.accessioned | 2018-11-22T16:56:33Z | - |
dc.date.available | 2018-11-22T16:56:33Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165742 | - |
dc.description.abstract | The purpose of this study was to investigate the expression of sarcosine metabolism-related proteins according to thyroid cancer subtypes and the implications of these findings. We performed tissue microarrays of 557 thyroid cancer cases (papillary thyroid carcinoma [PTC]: 344, follicular carcinoma [FC]: 112, medullary carcinoma [MC]: 70, poorly differentiated carcinoma [PDC]: 23, and anaplastic carcinoma [AC]: 8) and 152 follicular adenoma cases. Immunohistochemical staining for sarcosine metabolism-related molecules [glycine N-methyltransferase (GNMT), sarcosine dehydrogenase (SARDH), and l-pipecolic acid oxidase (PIPOX)] was conducted, and the results were analyzed based on clinicopathologic parameters. Results: The expression of SARDH and PIPOX was different depending on thyroid cancer subtypes. PTC showed higher expression than other subtypes (P<0.001). Among PTC, follicular variant (FV) showed lower expression than conventional type (P = 0.010 and P<0.001) and PTC with BRAF V600E mutation showed higher expression than PTC without BRAF V600E mutation (P<0.001). In univariate analysis, PIPOX positivity was associated with shorter overall survival (OS) in PTC (P = 0.024). In conclusion, the expression of sarcosine metabolism-related proteins varied according to thyroid cancer subtypes. SARDH and PIPOX showed higher expression in PTC; among PTC, FVPTC showed lower expression and PTC with BRAF V600E mutation showed higher expression. | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | e-Century Pub. Corp. | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Expression of sarcosine-metabolizing enzymes in thyroid cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Hye Min Kim | - |
dc.contributor.googleauthor | Yu Kyung Lee | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.localId | A04553 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J01096 | - |
dc.identifier.eissn | 1936-2625 | - |
dc.contributor.alternativeName | Kim, Hye Min | - |
dc.contributor.affiliatedAuthor | 김혜민 | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 7132 | - |
dc.citation.endPage | 7139 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.9(7) : 7132-7139, 2016 | - |
dc.identifier.rimsid | 58342 | - |
dc.type.rims | ART | - |
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