Cited 7 times in
Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients.
DC Field | Value | Language |
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dc.contributor.author | 강신애 | - |
dc.contributor.author | 김민진 | - |
dc.contributor.author | 남지선 | - |
dc.contributor.author | 박종숙 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 유지홍 | - |
dc.contributor.author | 이상배 | - |
dc.date.accessioned | 2018-11-16T17:01:05Z | - |
dc.date.available | 2018-11-16T17:01:05Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165576 | - |
dc.description.abstract | BACKGROUND: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients. METHODS: Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes. RESULTS: Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion. CONCLUSION: Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Endocrine Society | - |
dc.relation.isPartOf | Endocrinology and Metabolism (대한내분비학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ji Sun Nam | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.contributor.googleauthor | Sang Bae Lee | - |
dc.contributor.googleauthor | Ji Hong You | - |
dc.contributor.googleauthor | Min Jin Kim | - |
dc.contributor.googleauthor | Shinae Kang | - |
dc.contributor.googleauthor | Jong Suk Park | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.identifier.doi | 10.3803/EnM.2018.33.3.364 | - |
dc.contributor.localId | A00052 | - |
dc.contributor.localId | A05458 | - |
dc.contributor.localId | A01268 | - |
dc.contributor.localId | A01660 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A04984 | - |
dc.contributor.localId | A02817 | - |
dc.relation.journalcode | J00773 | - |
dc.identifier.eissn | 2093-5978 | - |
dc.identifier.pmid | 30229575 | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | Calpain 10 | - |
dc.subject.keyword | Diabetes mellitus, type 2 | - |
dc.contributor.alternativeName | Kang, Shin Ae | - |
dc.contributor.alternativeName | Kim, Min Jin | - |
dc.contributor.alternativeName | Nam, Ji Sun | - |
dc.contributor.alternativeName | Park, Jong Suk | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | You, Ji Hong | - |
dc.contributor.alternativeName | Lee, Sang Bae | - |
dc.contributor.affiliatedAuthor | 강신애 | - |
dc.contributor.affiliatedAuthor | 김민진 | - |
dc.contributor.affiliatedAuthor | 남지선 | - |
dc.contributor.affiliatedAuthor | 박종숙 | - |
dc.contributor.affiliatedAuthor | 안철우 | - |
dc.contributor.affiliatedAuthor | 유지홍 | - |
dc.contributor.affiliatedAuthor | 이상배 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 364 | - |
dc.citation.endPage | 371 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism (대한내분비학회지), Vol.33(3) : 364-371, 2018 | - |
dc.identifier.rimsid | 59209 | - |
dc.type.rims | ART | - |
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